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Methodologies to Identify and Analyze Genetic Polymorphisms for Human Histamine Receptors

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Histamine Receptors as Drug Targets

Part of the book series: Methods in Pharmacology and Toxicology ((MIPT))

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Abstract

Histamine is a biogenic amine that has an inherent biological importance in many physiological functions. With the new genomic era we are facing, personalized care and treatment is becoming one of the major focal points in research. This chapter will focus on the tools available to assess polymorphisms and genetic variations in the human histamine receptor family. The genetic composition of this receptor family is discussed and explained. Methodologies in genetic analysis are described, the use of bioinformatics information available is explored, and the use of Hapmap data and how it can be used in genome-wide association studies and linkage analysis is explained. Bioinformatics and molecular biology prove to be essential tools in investigating genetic associations between genotype and disease. This area of research is of utmost importance for identification of biological markers and is essential in the search to develop personalized medication.

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Author information

Authors and Affiliations

  1. School of Pharmacy and Pharmaceutical Sciences, Panoz Institute, Trinity Biomedical Sciences Institute, Trinity College, College Green, Dublin 2, Ireland

    Stephany Micallef & Astrid Sasse

Authors
  1. Stephany Micallef
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  2. Astrid Sasse
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Corresponding author

Correspondence to Astrid Sasse .

Editor information

Editors and Affiliations

  1. Department of Pharmacology Medical School, National and Kapodistrian University of Athens, Athens, Greece

    Ekaterini Tiligada

  2. Centre for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen’s University Belfast, Belfast, Northern Ireland, United Kingdom

    Madeleine Ennis

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Micallef, S., Sasse, A. (2017). Methodologies to Identify and Analyze Genetic Polymorphisms for Human Histamine Receptors. In: Tiligada, E., Ennis, M. (eds) Histamine Receptors as Drug Targets. Methods in Pharmacology and Toxicology. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-6843-5_1

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  • DOI: https://doi.org/10.1007/978-1-4939-6843-5_1

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-6841-1

  • Online ISBN: 978-1-4939-6843-5

  • eBook Packages: Springer Protocols

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