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Development of Computational Models of cAMP Signaling

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cAMP Signaling

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1294))

Abstract

Despite the growing evidence defining the cAMP signaling network as a master regulator of cellular function in a number of tissues, regulatory feedback loops, signal compartmentalization, as well as cross-talk with other signaling pathways make understanding the emergent properties of cAMP cellular action a daunting task. Dynamical models of signaling that combine quantitative rigor with molecular details can contribute valuable mechanistic insight into the complexity of intracellular cAMP signaling by complementing and guiding experimental efforts. In this chapter, we review the development of cAMP computational models. We describe how features of the cAMP network can be represented and review the types of experimental data useful in modeling cAMP signaling. We also compile a list of published cAMP models that can aid in the development of novel dynamical models of cAMP signaling.

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Authors and Affiliations

  1. Department of Pharmacology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA

    Susana R. Neves-Zaph Ph.D. & Roy S. Song

  2. Department of Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA

    Susana R. Neves-Zaph Ph.D. & Roy S. Song

  3. Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA

    Susana R. Neves-Zaph Ph.D.

  4. System Biology Center New York, Icahn School of Medicine at Mount Sinai, Icahn Building, 12th floor, Room 12-70e, 1425 Madison Avenue, One Gustave L. Levy Place, Box 1215, New York, NY, 10029, USA

    Susana R. Neves-Zaph Ph.D.

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  1. Susana R. Neves-Zaph Ph.D.
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  2. Roy S. Song
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Corresponding author

Correspondence to Susana R. Neves-Zaph Ph.D. .

Editor information

Editors and Affiliations

  1. Department of Physiology, Anatomy, and Genetics, University of Oxford, Oxford, United Kingdom

    Manuela Zaccolo

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Neves-Zaph, S.R., Song, R.S. (2015). Development of Computational Models of cAMP Signaling. In: Zaccolo, M. (eds) cAMP Signaling. Methods in Molecular Biology, vol 1294. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-2537-7_16

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  • DOI: https://doi.org/10.1007/978-1-4939-2537-7_16

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-2536-0

  • Online ISBN: 978-1-4939-2537-7

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