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Immunoinformatics: A Brief Review

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Immunoinformatics

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1184))

Abstract

A large volume of data relevant to immunology research has accumulated due to sequencing of genomes of the human and other model organisms. At the same time, huge amounts of clinical and epidemiologic data are being deposited in various scientific literature and clinical records. This accumulation of the information is like a goldmine for researchers looking for mechanisms of immune function and disease pathogenesis. Thus the need to handle this rapidly growing immunological resource has given rise to the field known as immunoinformatics. Immunoinformatics, otherwise known as computational immunology, is the interface between computer science and experimental immunology. It represents the use of computational methods and resources for the understanding of immunological information. It not only helps in dealing with huge amount of data but also plays a great role in defining new hypotheses related to immune responses. This chapter reviews classical immunology, different databases, and prediction tool. Further, it briefly describes applications of immunoinformatics in reverse vaccinology, immune system modeling, and cancer diagnosis and therapy. It also explores the idea of integrating immunoinformatics with systems biology for the development of personalized medicine. All these efforts save time and cost to a great extent.

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Acknowledgment

Ms. Namrata Tomar, one of the authors, gratefully acknowledges CSIR, India, for providing her a Senior Research Fellowship (9/93(0145)/12, EMR-I).

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  1. Machine Intelligence Unit, Indian Statistical Institute, 203 B.T. Road, Kolkata, 700108, India

    Namrata Tomar & Rajat K. De

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  1. Namrata Tomar
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Correspondence to Rajat K. De .

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  1. Indian Statistical Institute, Kolkata, West Bengal, India

    Rajat K. De

  2. Indian Statistical Institute, Kolkata, West Bengal, India

    Namrata Tomar

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Tomar, N., De, R.K. (2014). Immunoinformatics: A Brief Review. In: De, R., Tomar, N. (eds) Immunoinformatics. Methods in Molecular Biology, vol 1184. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-1115-8_3

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  • DOI: https://doi.org/10.1007/978-1-4939-1115-8_3

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