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In Vitro Systems for Hepatotoxicity Testing

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In Vitro Toxicology Systems

Part of the book series: Methods in Pharmacology and Toxicology ((MIPT))

Abstract

Hepatotoxicity is the most frequent reason of drug withdrawal from the market. Therefore, hepatocyte in vitro systems that predict human hepatotoxicity are of high importance. Although some progress has been achieved in predicting toxicity formation of major metabolites and enzyme induction (Hewitt et al., Drug Metab Rev 39:159–234, 2007; Hengstler et al., Chem Biol Interact 125:51–73, 2000) it is still difficult to reliably predict idiosyncratic drug-induced liver injury (iDILI), a particularly worrying form of hepatotoxicity that can arise from many commonly prescribed drugs (Godoy et al., Arch Toxicol 87:1315–1530, 2013; Amacher, Expert Opin Drug Metab Toxicol 8:335–347, 2012). This chapter describes currently available hepatocyte in vitro systems and their possibilities as well as limitations in studying hepatotoxicity and ADME.

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Authors and Affiliations

  1. Leibniz-Institut für Arbeitsforschung an der TU Dortmund, Ardeystrasse 67, 44139, Dortmund, Germany

    Jan G. Hengstler, Seddik Hammad, Ahmed Ghallab, Raymond Reif & Patricio Godoy

  2. Department of Forensic and Veterinary Toxicology, Faculty of Veterinary Medicine, South Valley University, Qena, Egypt

    Seddik Hammad & Ahmed Ghallab

Authors
  1. Jan G. Hengstler
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  2. Seddik Hammad
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  3. Ahmed Ghallab
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  4. Raymond Reif
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  5. Patricio Godoy
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Correspondence to Jan G. Hengstler .

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Editors and Affiliations

  1. European Commission Joint Research Centre, Ispra, Varese, Italy

    Anna Bal-Price

  2. Innsbruck Medical University, Innsbruck, Austria

    Paul Jennings

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Hengstler, J.G., Hammad, S., Ghallab, A., Reif, R., Godoy, P. (2014). In Vitro Systems for Hepatotoxicity Testing. In: Bal-Price, A., Jennings, P. (eds) In Vitro Toxicology Systems. Methods in Pharmacology and Toxicology. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-0521-8_2

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  • DOI: https://doi.org/10.1007/978-1-4939-0521-8_2

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