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Exploring Protein Intrinsic Disorder with MobiDB

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Intrinsically Disordered Proteins

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2141))

Abstract

Nowadays, it is well established that many proteins or regions under physiological conditions lack a fixed three-dimensional structure and are intrinsically disordered. MobiDB is the main repository of protein disorder and mobility annotations, combining different data sources to provide an exhaustive overview of intrinsic disorder. MobiDB includes curated annotations from other databases, indirect disorder evidence from structural data, and disorder predictions from protein sequences. It provides an easy-to-use web server to visualize and explore disorder information. This chapter describes the data available in MobiDB, emphasizing how to use and access the intrinsic disorder data. MobiDB is available at URL http://mobidb.bio.unipd.it.

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Acknowledgments

Authors would like to thank Diana Battistella for helping us with manuscript proofreading.

Author information

Authors and Affiliations

  1. Department of Biomedical Sciences, University of Padua, Padua, Italy

    Alexander Miguel Monzon, András Hatos, Marco Necci, Damiano Piovesan & Silvio C. E. Tosatto

  2. CNR Institute of Neuroscience, Padua, Italy

    Silvio C. E. Tosatto

Authors
  1. Alexander Miguel Monzon
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  2. András Hatos
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  3. Marco Necci
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  4. Damiano Piovesan
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  5. Silvio C. E. Tosatto
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Corresponding author

Correspondence to Silvio C. E. Tosatto .

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Editors and Affiliations

  1. Structural Biology and NMR Laboratory, Department of Biology, University of Copenhagen, København N, Denmark

    Birthe B. Kragelund

  2. Linderstrøm-Lang Centre for Protein Science, Department of Biology, University of Copenhagen, Copenhagen, Denmark

    Karen Skriver

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Monzon, A.M., Hatos, A., Necci, M., Piovesan, D., Tosatto, S.C.E. (2020). Exploring Protein Intrinsic Disorder with MobiDB. In: Kragelund, B.B., Skriver, K. (eds) Intrinsically Disordered Proteins. Methods in Molecular Biology, vol 2141. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-0524-0_6

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  • DOI: https://doi.org/10.1007/978-1-0716-0524-0_6

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  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-0716-0523-3

  • Online ISBN: 978-1-0716-0524-0

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