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Multifunctional Nanodelivery Platform for Maximizing Nucleic Acids Combination Therapy

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RNA Interference and CRISPR Technologies

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2115))

Abstract

The silencing of an oncogene with a small interfering RNA (siRNA) is a promising way for cancer therapy. Its efficacy can be further enhanced by integrating with other therapeutics; however, transporting siRNA and other active ingredients to the same location at the same time is challenging. Here, we report a novel multifunctional nanodelivery platform by sequentially layering several functional ingredients, such as siRNAs, microRNAs, peptides, and targeting ligands, onto a core through charge–charge interaction. The prepared nanovectors effectively and programmably delivered multiple active components to maximize therapeutic combination with minimal off-targeting effects.

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Acknowledgments

This study was supported in part by NIH CA135312 and DOD W81XWH-11-1-0442.

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Authors and Affiliations

  1. Department of Radiology, Weill Cornell Medicine, Molecular Imaging Innovations Institute, New York, NY, USA

    Seung Koo Lee, Benedict Law & Ching-Hsuan Tung

Authors
  1. Seung Koo Lee
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  2. Benedict Law
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  3. Ching-Hsuan Tung
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Corresponding author

Correspondence to Ching-Hsuan Tung .

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Editors and Affiliations

  1. Department of Cancer Immunology, Institute for Cancer Research, Oslo University Hospital-Radiumhospitalet, Oslo, Norway

    Mouldy Sioud

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Lee, S.K., Law, B., Tung, CH. (2020). Multifunctional Nanodelivery Platform for Maximizing Nucleic Acids Combination Therapy. In: Sioud, M. (eds) RNA Interference and CRISPR Technologies. Methods in Molecular Biology, vol 2115. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-0290-4_4

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  • DOI: https://doi.org/10.1007/978-1-0716-0290-4_4

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  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-0716-0289-8

  • Online ISBN: 978-1-0716-0290-4

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