Abstract
Corneal transplantation for the treatment of corneal blindness is challenging in many countries due to the shortage of graft procurement. Xenocorneal transplantation is an interesting alternative to explore despite immunologic rejection, which mainly involves endothelial cells. As anterior lamellar keratoplasty, when indicated, shows less immunologic reaction, we developed and describe below a pig-to-non-human-primate model of anterior lamellar corneal xenograft. This model can be used to assess the efficacy of corneas from genetically modified pigs.
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Acknowledgments
The author would like to thank Stephanie Le Bas-Bernardet, David Minault, Jeremy Hervouet, Veronique Daguin, and Annaıck Pallier, for their collaboration; Simon C. Robson, Mark B. Nottle, Peter J. Cowan, Eric Venturi, Pascal Mermillod, Philippe Brachet, Cesare Galli, Irina Lagutina, and Roberto Duchi, for allowing us to work on transgenic pig lines; and Gilles Blancho, Jean-Paul Soulillou, and Bernard Vanhove for their active support and helpful advices.
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Vabres, B., Vanhove, B., Blancho, G. (2020). Corneal Xenotransplantation: Anterior Lamellar Keratoplasty. In: Costa, C. (eds) Xenotransplantation. Methods in Molecular Biology, vol 2110. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-0255-3_16
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DOI: https://doi.org/10.1007/978-1-0716-0255-3_16
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Publisher Name: Humana, New York, NY
Print ISBN: 978-1-0716-0254-6
Online ISBN: 978-1-0716-0255-3
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