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Managing Drug Resistance in Cancer: Role of Cancer Informatics

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Cancer Drug Resistance

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1395))

Abstract

Understanding and managing cancer drug resistance is the main goal of the modern oncology programs worldwide. One of the major factors contributing to drug resistance in cancer cells is the acquired mutations in drug targets. Advances in sequencing technologies and high-throughput screening assays have generated huge information related to pharmaco-profiling of anticancer drugs and revealed the mutational spectrum of different cancers. Systematic meta-analysis of this complex data is very essential to make useful conclusions in order to manage cancer drug resistance. Bioinformatics can play a significant role to interpret this complex data into useful conclusions. In this chapter, the use of bioinformatics platforms, particularly CancerDR, in understanding the cancer drug resistance is described.

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Authors and Affiliations

  1. Bioinformatics Centre, CSIR-Institute of Microbial Technology, Sector 39A, Chandigarh, 160036, India

    Ankur Gautam, Kumardeep Chaudhary, Rahul Kumar, Sudheer Gupta, Harinder Singh & Gajendra P. S. Raghava

Authors
  1. Ankur Gautam
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  2. Kumardeep Chaudhary
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  3. Rahul Kumar
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  4. Sudheer Gupta
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  5. Harinder Singh
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  6. Gajendra P. S. Raghava
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Corresponding author

Correspondence to Gajendra P. S. Raghava .

Editor information

Editors and Affiliations

  1. New University of Lisbon, Lisbon, Portugal

    Jose Rueff

  2. New University of Lisbon, Lisbon, Portugal

    António Sebastião Rodrigues

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© 2016 Springer Science+Business Media New York

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Gautam, A., Chaudhary, K., Kumar, R., Gupta, S., Singh, H., Raghava, G.P.S. (2016). Managing Drug Resistance in Cancer: Role of Cancer Informatics. In: Rueff, J., Rodrigues, A. (eds) Cancer Drug Resistance. Methods in Molecular Biology, vol 1395. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-3347-1_17

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  • DOI: https://doi.org/10.1007/978-1-4939-3347-1_17

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-3345-7

  • Online ISBN: 978-1-4939-3347-1

  • eBook Packages: Springer Protocols

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