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Bioinformatics Approach to Understanding Interacting Pathways in Neuropsychiatric Disorders

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Clinical Bioinformatics

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1168))

Abstract

Bioinformatics-based applications have been incorporated into several medical disciplines, including cancer, neuroscience, and recently psychiatry. Both the increasing interest in the molecular aspect of neuropsychiatry and the availability of high-throughput discovery and analysis tools have encouraged the incorporation of bioinformatics and neurosystems biology techniques into psychiatry and neuroscience research. As applied to neuropsychiatry, systems biology involves the acquisition and processing of high-throughput datasets to infer new information. A major component in bioinformatics output is pathway analysis that provides an insight into and prediction of possible underlying pathogenic processes which may help understand disease pathogenesis. In addition, this analysis serves as a tool to identify potential biomarkers implicated in these disorders. In this chapter, we summarize the different tools and algorithms used in pathway analysis along with their applications to the different layers of molecular investigations, from genomics to proteomics.

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Abbreviations

CNVs:

Copy number variants

GWAS:

Genome-wide association study

SNPs:

Single-nucleotide polymorphisms

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Author information

Authors and Affiliations

  1. Department of Neurosciences, Medical University of South Carolina, Charleston, SC, USA

    Ali Alawieh

  2. Department of Electrical and Computer Engineering, Faculty of Engineering and Architecture, American University of Beirut, Beirut, Lebanon

    Zahraa Sabra, Atlal El-Assaad & Fadi Zaraket

  3. Department of Biochemistry and Molecular Genetics, American University of Beirut, Beirut, Lebanon

    Amaly Nokkari

  4. Department of Neurosciences, University of Messina, Messina, Italy

    Stefania Mondello

  5. Department of Electrical and Computer Engineering, College of Engineering, University of Florida, Gainesville, FL, USA

    Bilal Fadlallah

  6. Department of Biochemistry and Molecular Genetics, American University of Beirut, DTS Building, Room 1-50, 110236/41, Beirut, 1107-2020, Lebanon

    Firas H. Kobeissy

Authors
  1. Ali Alawieh
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  2. Zahraa Sabra
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  3. Amaly Nokkari
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  4. Atlal El-Assaad
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  5. Stefania Mondello
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  6. Fadi Zaraket
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  7. Bilal Fadlallah
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  8. Firas H. Kobeissy
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Corresponding author

Correspondence to Firas H. Kobeissy .

Editor information

Editors and Affiliations

  1. Department of Medical Genomics, Royal Prince Alfred Hospital and Sydney Medical School, University of Sydney, Camperdown, Australia

    Ronald Trent

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Alawieh, A. et al. (2014). Bioinformatics Approach to Understanding Interacting Pathways in Neuropsychiatric Disorders. In: Trent, R. (eds) Clinical Bioinformatics. Methods in Molecular Biology, vol 1168. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-0847-9_9

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  • DOI: https://doi.org/10.1007/978-1-4939-0847-9_9

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-0846-2

  • Online ISBN: 978-1-4939-0847-9

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