Overview
- Nominated as an outstanding contribution by the University of Oxford
- Presents a novel model with remarkable explanatory power
- Holds important potential for dynamic DNA nanotechnology
- Includes supplementary material: sn.pub/extras
- Includes supplementary material: sn.pub/extras
Part of the book series: Springer Theses (Springer Theses)
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About this book
This thesis presents a novel coarse-grained model of DNA, in which bases are represented as rigid nucleotides. The model is shown to quantitatively reproduce many phenomena, including elastic properties of the double-stranded state, hairpin formation in single strands and hybridization of pairs of strands to form duplexes, the first time such a wide range of properties has been captured by a coarse-grained model. The scope and potential of the model is demonstrated by simulating DNA tweezers, an iconic nanodevice, and a two-footed DNA walker — the first time that coarse-grained modelling has been applied to dynamic DNA nanotechnology.
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Table of contents (9 chapters)
Authors and Affiliations
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Bibliographic Information
Book Title: Coarse-Grained Modelling of DNA and DNA Self-Assembly
Authors: Thomas E. Ouldridge
Series Title: Springer Theses
DOI: https://doi.org/10.1007/978-3-642-30517-7
Publisher: Springer Berlin, Heidelberg
eBook Packages: Physics and Astronomy, Physics and Astronomy (R0)
Copyright Information: Springer-Verlag Berlin Heidelberg 2012
Hardcover ISBN: 978-3-642-30516-0Published: 07 July 2012
Softcover ISBN: 978-3-642-43652-9Published: 09 August 2014
eBook ISBN: 978-3-642-30517-7Published: 09 July 2012
Series ISSN: 2190-5053
Series E-ISSN: 2190-5061
Edition Number: 1
Number of Pages: XII, 176
Topics: Biological and Medical Physics, Biophysics, Nanotechnology, Polymer Sciences, Complex Systems, Soft and Granular Matter, Complex Fluids and Microfluidics, Statistical Physics and Dynamical Systems