Overview
- Provides a state-of-the-art review on nuclear structure and functions
- Highlights the relation between epigenomics and nuclear architecture
- Gives an outlook on possible medical applications
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About this book
This book gives an in-depth overview on nuclear structure and function. It clearly shows that the epigenome and the three-dimensional organization of the nucleus are not independent properties. The intimate relationship between the location and the epigenetic modifications of gene loci is highlighted. Finally, it shows that the complex three-dimensional organization of the nucleus is not just of academic interest: The structure, composition and function of virtually all of the sub-nuclear compartments identified so far can be implicated to a list of human genetic diseases. Hence, a detailed elucidation of how these domains are assembled and function will provide new opportunities for therapeutic intervention in clinical practice.
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Keywords
Table of contents (21 chapters)
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Nuclear Periphery
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Chromosomes
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Nuclear Domains and Development
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Nuclear Domains and Cell Stress
Editors and Affiliations
About the editors
The Hospital for Sick Children, Toronto, ON, Canada
Graham Dellaire
Dalhousie University, Halifax, NS, Canada
Bibliographic Information
Book Title: The Functional Nucleus
Editors: David P. Bazett-Jones, Graham Dellaire
DOI: https://doi.org/10.1007/978-3-319-38882-3
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer International Publishing Switzerland 2016
Hardcover ISBN: 978-3-319-38880-9Published: 25 October 2016
Softcover ISBN: 978-3-319-81768-2Published: 23 June 2018
eBook ISBN: 978-3-319-38882-3Published: 17 October 2016
Edition Number: 1
Number of Pages: VI, 513
Number of Illustrations: 8 b/w illustrations, 48 illustrations in colour
Topics: Nucleic Acid Chemistry, Cell Biology, Cytogenetics