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Cell Engineering and Regeneration

  • Living reference work
  • © 2020

Overview

Editors:
  1. Jeffrey M. Gimble

    1. Tulane Univ. Sch. of Medicine, New Orleans, USA

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  2. Darja Marolt Presen

    1. AUVA Center, Ludwig Boltzmann Institute for Experimen, Wien, Austria

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  3. Richard O. C. Oreffo

    1. Human Development and Health, University of Southampton, Southampton, United Kingdom

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  4. Susanne Wolbank

    1. AUVA Center, Ludwig Boltzmann Institute for Experimen, Vienna, Austria

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  5. Heinz Redl

    1. Experimental and Clinical Traumatol, Ludwig Boltzmann Institute for, Wien, Austria

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  • Provides cutting-edge research in this discipline
  • Includes contributions from the TERMIS community
  • Addresses both clinical practitioners and researchers in academia
  • Written by international experts in the field

Part of the book series: Reference Series in Biomedical Engineering (RSBE)

Part of the book sub series: Tissue Engineering and Regeneration (TIENRE)

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About this book

This reference work presents the origins of cells for tissue engineering and regeneration, including primary cells, tissue-specific stem cells, pluripotent stem cells and trans-differentiated or reprogrammed cells. There is particular emphasis on current understanding of tissue regeneration based on embryology and evolution studies, including mechanisms of amphibian regeneration. The book covers the use of autologous versus allogeneic cell sources, as well as various procedures used for cell isolation and cell pre-conditioning , such as cell sorting, biochemical and biophysical pre-conditioning, transfection and aggregation. It also presents cell modulation using growth factors, molecular factors, epigenetic approaches, changes in biophysical environment, cellular co-culture and other elements of the cellular microenvironment. The pathways of cell delivery are discussed with respect to specific clinical situations, including delivery of ex vivo manipulated cells via local and systemic routes, as well as activation and migration of endogenous reservoirs of reparative cells. The volume concludes with an in-depth discussion of the tracking of cells in vivo and their various regenerative activities inside the body, including differentiation, new tissue formation and actions on other cells by direct cell-to-cell communication and by secretion of biomolecules.

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Keywords

Table of contents (26 entries)

  1. Cells for Cartilage Regeneration

    • Gerjo J. V. M. van Osch, Andrea Barbero, Mats Brittberg, Diego Correa, Solvig Diederichs, Mary B. Goldring et al.

  2. Overview of Cell Types Capable of Contributing to Skeletal Muscle Repair and Regeneration

    • Johanna Pruller, Peter S. Zammit

  3. Pancreatic Islet Beta-Cell Replacement Strategies

    • J. Jason Collier, Susan J. Burke

  4. The Role of Schwann Cells in Peripheral Nerve Function, Injury, and Repair

    • Christina M. A. P. Schuh, Ana Maria Sandoval-Castellanos, Cristian De Gregorio, Pamina Contreras-Kallens, John W. Haycock

  5. Periosteum Derived Cells in Skeletal Tissue Regeneration

    • Johanna Bolander, Tim Herpelinck, Frank P. Luyten

  6. Bone-Marrow-Derived Mesenchymal Stromal Cells: From Basic Biology to Applications in Bone Tissue Engineering and Bone Regeneration

    • Janja Zupan, Daniel Tang, Richard O. C. Oreffo, Heinz Redl, Darja Marolt Presen

  7. Stem Cells: Umbilical Cord/Wharton’s Jelly Derived

    • John T. Walker, Armand Keating, John E. Davies

  8. Hair Follicle Stem Cells and Hair Regeneration

    • Sung-Jan Lin, Wen-Yen Huang, Chih-Chiang Chen, Mingxing Lei, Jin-Bon Hong

  9. Embryonic Stem Cells

    • Philip Lewis, Edina Silajdžić, Daniel R. Brison, Susan J. Kimber

  10. Use of Xenogeneic Cells

    • Elisabeth Kemter, Alexander Kind, Bruno Reichart, Eckhard Wolf

  11. Hard Material Modulation for (Skeletal) Tissue Engineering Purposes

    • Paul E. Bourgine

  12. Cell Sheets for Tissue Engineering Applications

    • Ram V. Devireddy

  13. microRNA Modulation

    • Irene Mencía Castaño, Rosanne M. Raftery, Caroline M. Curtin, Johannes Grillari, Heinz Redl, Fergal J. O’Brien

  14. Epigenetics and Its Implications for Tissue Regeneration and Regenerative Medicine with a Focus on DNA-Methylation

    • K. Hanak, W. Neuhaus, A. Weinhäusel

  15. Seeing Is Believing: Noninvasive Microscopic Imaging Modalities for Tissue Engineering and Regenerative Medicine

    • Nuno Neto, Ruslan I. Dmitriev, Michael G. Monaghan

  16. Mesenchymal Stromal Cell Secretome for Tissue Repair

    • Massimiliano Gnecchi, Maria Chiara Ciuffreda, Manuela Mura

  17. Molecular Crowding – (in Cell Culture)

    • Cedric Badowski, Aneesa Iskander, Diana Gaspar, Dimitrios I. Zeugolis, Michael Raghunath

  18. Biological Augmentation for Tendon Repair: Lessons to be Learned from Development, Disease, and Tendon Stem Cell Research

    • Herbert Tempfer, Christine Lehner, Moritz Grütz, Renate Gehwolf, Andreas Traweger

  19. Challenges and Status of Adipose Cell Therapies: Translation and Commercialization

    • Tosan E. Ehanire, Adam J. Katz

  20. Cell Culture Conditions: Cultivation of Stem Cells Under Dynamic Conditions

    • Andreas Clementi, Dominik Egger, Verena Charwat, Cornelia Kasper
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Editors and Affiliations

  • Tulane Univ. Sch. of Medicine, New Orleans, USA

    Jeffrey M. Gimble

  • AUVA Center, Ludwig Boltzmann Institute for Experimen, Wien, Austria

    Darja Marolt Presen

  • Human Development and Health, University of Southampton, Southampton, United Kingdom

    Richard O. C. Oreffo

  • AUVA Center, Ludwig Boltzmann Institute for Experimen, Vienna, Austria

    Susanne Wolbank

  • Experimental and Clinical Traumatol, Ludwig Boltzmann Institute for, Wien, Austria

    Heinz Redl

About the editors

Prof. Heinz Redl has served as Director of the Ludwig Boltzmann Institute for Experimental and Clinical Traumatology (LBI Trauma), part of the AUVA Research Center, since 1998 and is the founder of Trauma Care Consult, a company intended to promote collaboration with industry. His goals are to improve the diagnostic and therapeutic options available to trauma patients, and to establish new national and international networks – as can be seen in the 2006 launch of the Austrian Cluster for Tissue Regeneration and subsequent creation of the European Institute of Excellence for Tissue Engineering and Regenerative Medicine (Expertissue), which he co-founded.

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