Overview
- Editors:
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Daniele D’Ambrosio
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BioXell S.p.A., Milan, Italy
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Francesco Sinigaglia
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BioXell S.p.A., Milan, Italy
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Table of contents (21 protocols)
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- Silvano Sozzani, Annunciata Vecchi, Paola Allavena, Alberto Mantovani
Pages 1-15
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- Paul Proost, Frank Mahieu, Evemie Schutyser, Jo Van Damme
Pages 27-44
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- Lucia Colantonio, Andrea Iellem, Daniele D’Ambrosio
Pages 45-52
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- Miguel Vicente-Manzanares, Mariano VitÓn, Francisco Sánchez-Madrid
Pages 53-68
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- Angela Gismondi, Fabrizio Mainiero, Angela Santoni
Pages 69-75
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- Peter Friedl, Eva-B. Bröcker
Pages 77-90
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- Mark A. Landree, Peter N. Devreotes
Pages 91-104
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- Sergio A. Lira, Borna Mehrad, Shu-Cheng Chen, Petronio Zalamea, David J. Kinsley, Maria T. Wiekowski et al.
Pages 105-122
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- Denise C. Cara, Paul Kubes
Pages 123-131
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- Claire L. Adams, Catherine M. Rush, Karen M. Smith, Paul Garside
Pages 133-146
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- Margherita Mariani, Paola Panina-Bordignon
Pages 147-165
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- Clare M. Lloyd, Jose-Carlos Gutierrez-Ramos
Pages 199-209
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- Adam P. Curnock, Yannis Sotsios, Stephen G. Ward
Pages 211-221
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- Giovanni Bernardini, Domenico Ribatti, Gaia Spinetti, Lucia Morbidelli, Marina Ziche, Angela Santoni et al.
Pages 223-232
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About this book
Chemokines and their receptors play a central role in the pathogenesis of numerous, perhaps all, acute and chronic inflammatory diseases. About 50 distinct chemokines produced by a variety cell types and tissues either c- stitutively or in response to inflammatory stimuli are involved in a plethora of biological processes. These small secreted proteins exert their exquisitely variegated functions upon binding to a family of seven-transmembrane spanning G-protein coupled receptors (GPCRs) composed of almost 20 distinct entities. The biological activities of chemokines range from the control of leukocyte trafficking in basal and inflammatory conditions to the regulation of hema- poiesis, angiogenesis, tissue architecture, and organogenesis. The basis for such diversified activities rests, on one hand, upon the ubiquitous nature of chemokine production and chemokine receptor expression. Virtually every cell type can produce chemokines and expresses a unique combination of chemokine receptors. On the other hand, chemokine receptors make use of a flexible and complex network of intracellular signaling machineries that can regulate a variety of cellular functions ranging from cell migration, growth, and differentiation to death. As knowledge of the size of chemokine and chemokine receptor families rapidly reaches completeness, much is still to be uncovered in terms of fu- tional architecture of the chemokine system. The disparity between the large number of chemokines and that smaller number of receptors is balanced by the promiscuity in ligand–receptor interactions, with multiple chemokines binding to the same receptor and several chemokines binding to more than one receptor.
