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Cancer Metastasis and the Lymphovascular System:

Basis for Rational Therapy

  • Book
  • © 2007

Overview

Editors:
  1. Stanley P. L. Leong

    1. University of California San Francisco and UCSF Comprehensive Cancer Center at Mount Zion, San Francisco, USA

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  • Characterizes the anatomy and physiology of the lymphovascular system
  • Describes the mechanisms of metastasis
  • Outlines the prognostic factors and clinical outcome of metastasis
  • Provides readers with an understanding of immune responses of draining lymph nodes against cancer
  • Explains the rationale of adopting molecular therapeutics against growth factor receptors, apoptotic factors, signaling pathways and angiogenesis

Part of the book series: Cancer Treatment and Research (CTAR, volume 135)

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Table of contents (21 chapters)

  1. Front Matter

    Pages i-xvi
    Download chapter PDF

  2. Landmarks and Advances in Translational Lymphology

    • Marlys H. Witte, Kimberly Jones, Michael Bernas, Charles L. Witte
    Pages 1-16

  3. Embryonic Development of the Lymphovascular System and Tumor Lymphangiogenesis

    • Jörg Wilting, Maria Papoutsi, Kerstin Buttler, Jürgen Becker
    Pages 17-24

  4. Lymphatic Origin from Embryonic Stem Cells

    • Michael Dictor, Sofia Mebrahtu, Manuel Selg, Zerina Lokmic, Lydia Sorokin
    Pages 25-37

  5. Lymphatic Markers, Tumour Lymphangiogenesis and Lymph Node Metastasis

    • David G. Jackson
    Pages 39-53

  6. Anatomy of the Human Lymphatic System

    • Mauro Andrade, Alfredo Jacomo
    Pages 55-77

  7. SPECT–CT Fusion Imaging Radionuclide Lymphoscintigraphy: Potential for Limb Lymphedema Assessment and Sentinel Node Detection In Breast Cancer

    • Alain P. Pecking, W. Wartski, R. V. Cluzan, D. Bellet, J. L. Albérini
    Pages 79-84

  8. Sentinel Node Identification using Radionuclides in Melanoma and Breast Cancer

    • Edwin Glass
    Pages 85-100

  9. Targeted Introduction of Substances into the Lymph Nodes for Endolymphatic Therapy

    • Peter Hirnle
    Pages 101-118

  10. Mechanisms of Metastasis: Seed and Soil

    • Adriano Piris, Martin C. Mihm
    Pages 119-127

  11. Preclinical Models of Regional Lymph Node Tumor Metastasis

    • S. David Nathanson
    Pages 129-156

  12. A New Breast Cancer Model for Lymphatic Metastasis

    • Michael M. Lizardo, Ian C. MacDonald, Alan B. Tuck, Ann F. Chambers
    Pages 157-165

  13. Lymph Node Micrometastases in Lung Cancer

    • Katharina E. Effenberger, Wulf Sienel, Klaus Pantel
    Pages 167-175

  14. Effects of Chemokines on Tumor Metastasis

    • Hiroya Takeuchi, Minoru Kitago, David S. B. Hoon
    Pages 177-184

  15. Regional Lymph Node Metastases, a Singular Manifestation of the Process of Clinical Metastases in Cancer: Contemporary Animal Research And Clinical Reports Suggest Unifying Concepts

    • Blake Cady
    Pages 185-201

  16. Patterns of Metastatsis in Head and Neck Cancer

    • Jochen A. Werner
    Pages 203-207

  17. Patterns of Metastasis in Human Solid Cancers

    • Stanley P. L. Leong, Blake Cady, David M. Jablons, Julio Garcia-Aguilar, Douglas Reintgen, Jochen A. Werner et al.
    Pages 209-221

  18. Significance of Regional Draining Lymph Nodes in the Development of Tumor Immunity: Implications for Cancer Immunotherapy

    • Rongxiu Zheng, Jorgen Kjaergaard, Walter T. Lee, Peter A. Cohen, Suyu Shu
    Pages 223-237

  19. Targeting Small Molecules in Cancer

    • Harold J. Wanebo, David Berz, Anthony Mega
    Pages 239-255

  20. Update on the Role of EGFR Inhibitors in Cancer Therapeutics

    • Michalis V. Karamouzis, Athanassios Argiris
    Pages 257-275
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Keywords

About this book

Sentinel lymph node (SLN) procedures have opened a window of opportunity for the study of micrometastasis. In eighty percent (80%) of metastasis there lies an orderly pattern of progression via the lymphatic network, while 20% of the time systemic metastasis occurs, bypassing the lymphatic system. During the past two decades, significant progress has been achieved in understanding the anatomical, functional, cellular and molecular aspects of the lymphovascular system and the metastasis process.

· Molecular imaging advances help to localize early cancers more precisely.

· Current status of the immune responses in the draining lymph nodes against cancer is summarized.

· New paradigms of early cancer growth, proliferation, overcoming apoptosis are exploited in the development of anticancer treatment.

In this book, basic scientists and clinicians exchange ideas so that laboratory findings can be applied to clinical dilemmas, and clinical problems can be targeted for research in the laboratory.

Editors and Affiliations

  • University of California San Francisco and UCSF Comprehensive Cancer Center at Mount Zion, San Francisco, USA

    Stanley P. L. Leong

Bibliographic Information

  • Book Title: Cancer Metastasis and the Lymphovascular System:

  • Book Subtitle: Basis for Rational Therapy

  • Editors: Stanley P. L. Leong

  • Series Title: Cancer Treatment and Research

  • DOI: https://doi.org/10.1007/978-0-387-69219-7

  • Publisher: Springer New York, NY

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer-Verlag US 2007

  • Hardcover ISBN: 978-0-387-69218-0Published: 06 August 2007

  • Softcover ISBN: 978-1-4899-9102-7Published: 21 September 2014

  • eBook ISBN: 978-0-387-69219-7Published: 05 September 2007

  • Series ISSN: 0927-3042

  • Series E-ISSN: 2509-8497

  • Edition Number: 1

  • Number of Pages: XVII, 309

  • Topics: Oncology, Hematology, Internal Medicine

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