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Immediate Early Genes in Sensory Processing, Cognitive Performance and Neurological Disorders

  • Book
  • © 2006

Overview

Editors:
  1. Raphael Pinaud

    1. Department of Neurobiology, Duke University Medical Center, Durham, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Liisa A. Tremere

    1. Department of Neurobiology, Duke University Medical Center, Durham, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Provides a compilation of the most up-to-date literature on the topic of immediate early genes (IEGs), by the leading authors of the field of molecular neuroscience

  • Includes supplementary material: sn.pub/extras

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Table of contents (14 chapters)

  1. Front Matter

    Pages i-x
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  2. The Use of Immediate Early Genes as Mapping Tools for Neuronal Activation: Concepts and Methods

    1. The Use of Immediate Early Genes as Mapping Tools for Neuronal Activation: Concepts and Methods

      • Thomas A. Terleph, Liisa A. Tremere
      Pages 1-10

  3. Immediate Early Gene Expression as Part of Sensory Processing

    1. Front Matter

      Pages 11-11
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    2. Regulation of Immediate Early Genes in the Visual Cortex

      • Raphael Pinaud, Thomas A. Terleph, R. William Currie, Liisa A. Tremere
      Pages 13-33

    3. Immediate Early Gene Regulation in the Auditory System

      • Claudio V. Mello, Raphael Pinaud
      Pages 35-56

    4. Immediate Early Genes and Sensory Maps of Olfactory and Gustatory Function

      • Monique Montag-Sallaz, Dirk Montag
      Pages 57-72

    5. Immediate Early Gene Expression in the Primary Somatosensory Cortex: Focus on the Barrel Cortex

      • Raphael Pinaud, Robert K. Filipkowski, Antonio F. Fortes, Liisa A. Tremere
      Pages 73-92

    6. Immediate Early Genes Induced in Models of Acute and Chronic Pain

      • Shanelle W. Ko
      Pages 93-110

  4. Immediate Early Gene Expression in Complex Systems and Higher Order Cognitive Function

    1. Front Matter

      Pages 111-111
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    2. Mapping Sleep-Wake Control with the Transcription Factor c-Fos

      • Samuel Deurveilher, Kazue Semba
      Pages 113-136

    3. c-Fos and Zif268 in Learning and Memory—Studies on Expression and Function

      • Robert K. Filipkowski, Ewelina Knapska, Leszek Kaczmarek
      Pages 137-158

    4. Immediate Early Genes and the Mapping of Environmental Representations in Hippocampal Neural Networks

      • John F. Guzowski
      Pages 159-176

    5. Neuronal Dysfunction and Cognitive Impairment Resulting from Inactivation of the Egr-Family Transcription Factor zif268

      • Sabrina Davis, Megan Libbey, Serge Laroche
      Pages 177-195

  5. Immediate Early Genes in Neurological Disorder: Clinical Implications

    1. Front Matter

      Pages 197-197
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    2. The Contribution of Immediate Early Genes to the Understanding of Brain Processing of Stressors

      • Antonio Armario
      Pages 199-221

    3. Transcriptional Control of Nerve Cell Death, Survival and Repair

      • Rachel Cameron, Mike Dragunow
      Pages 223-242

    4. Immediate Early Genes, Inducible Transcription Factors and Stress Kinases in Alzheimer’s Disease

      • Isidro Ferrer, Gabriel Santpere, Berta Puig
      Pages 243-260

    5. Parkinson’s Disease, the Dopamine System and Immediate Early Genes

      • Xiaoqun Zhang, Per Svenningsson
      Pages 261-290

  6. Back Matter

    Pages 291-293
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Keywords

About this book

Immediate early genes (IEGs) are a class of genes that are rapidly expressed without new protein synthesis and, in most cases, in direct response to synaptic input. The most widely studied IEGs in neurobiology encode transcription factors, with two popular examples being c-fos and NGFI-A (a.k.a., zif268 , egr-1, krox-24 and zenk). The activity-dependent expression of most inducible transcription factors has enabled neuroscientists to use their expression as mapping tools for neuronal activation, thereby enhancing our understanding of the anatomical and functional organization of the central nervous system (CNS). IEGs, however, are known to encode not only transcription factors, but a much wider variety of proteins including signaling molecules, growth factors and cytoskeletal proteins. IEGs are therefore both directly and indirectly implicated in the dynamic functional and anatomical restructuring of the CNS that permits the rapid integration of new sensory experience with pre-existing or on-going neural function. Finally, recent evidence suggests that IEGs may also be implicated in the initiation or amplification of aberrant signaling in connection with neuropathological disorders.

This book reviews and details experiments and theories that challenge the reader to expand their view on how IEG research is currently being used to advance our understanding of static and active brain circuits, enabling the processing, acquisition and storage of new information in healthy systems. In addition, we explore roles of IEGs in clinical neuropathology, with potential utility in molecular modeling, to highlight, on a go-forward basis, candidate mechanisms for novel targets in clinical intervention.

Editors and Affiliations

  • Department of Neurobiology, Duke University Medical Center, Durham, USA

    Raphael Pinaud, Liisa A. Tremere

Bibliographic Information

  • Book Title: Immediate Early Genes in Sensory Processing, Cognitive Performance and Neurological Disorders

  • Editors: Raphael Pinaud, Liisa A. Tremere

  • DOI: https://doi.org/10.1007/978-0-387-33604-6

  • Publisher: Springer New York, NY

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer-Verlag US 2006

  • Hardcover ISBN: 978-0-387-33603-9Published: 16 August 2006

  • Softcover ISBN: 978-1-4899-8743-3Published: 18 September 2014

  • eBook ISBN: 978-0-387-33604-6Published: 22 November 2006

  • Edition Number: 1

  • Number of Pages: X, 293

  • Topics: Neurosciences, Neurobiology, Molecular Medicine

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