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Exploring the Vertebrate Central Cholinergic Nervous System

  • Book
  • © 2007

Overview

Editors:
  1. Alexander G. Karczmar

    1. Department of the Army, Washington, USA
      Department of Pharmacology and Experimental Therapeutics, Loyola University Medical Center, Maywood
      Edward J. Hines, Jr., VA Hospital, Hines, USA

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  • Provides complete, historically-based coverage of the central cholinergic system

  • Explores synaptic transmission, the peripheral nervous system, neuropharmacology, and the associated neurological diseases and aging

  • Includes supplementary material: sn.pub/extras

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Table of contents (11 chapters)

  1. Front Matter

    Pages i-xiii
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  2. Introduction:History and Scope of This Book

    Pages 1-31

  3. Cholinergic Cells and Pathways

    Pages 33-79

  4. Metabolism of Acetylcholine: Synthesis and Turnover

    Pages 81-149

  5. History of Research on Nicotinic and Muscarinic Cholinergic Receptors

    • Alexander G. Karczmar, Jon Lindstrom, Arthur Christopoulos
    Pages 151-162

  6. Muscarinic Acetylcholine Receptors in the Central Nervous System: Structure, Function, and Pharmacology

    • Arthur Christopoulos
    Pages 163-208

  7. Neuronal Nicotinic Receptors: History, Structure, and Functional Roles

    • Jon Lindstrom
    Pages 209-235

  8. Anticholinesterases and War Gases

    Pages 237-310

  9. Cholinergic Aspects of Growth and Development

    Pages 311-409

  10. Central Cholinergic Nervous System and Its Correlates

    Pages 411-596

  11. Links Between Amyloid and Tau Biology in Alzheimer’s Disease and Their Cholinergic Aspects

    • George J. Siegel, Neelima Chauhan, Alexander G. Karczma
    Pages 597-656

  12. Envoi

    Pages 657-665

  13. Back Matter

    Pages 667-686
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Keywords

About this book

Even if the “weapons of mass destruction” (WMD) and, among them, stocks of organoph- phorus (OP) agents (also referred to as war gases and nerve gases) were not found in Iraq following the US-Iraq war, the relative ease with which these substances can be made from harmless precursors and the low cost of their manufacture will continue to fascinate pow- hungry, ruthless dictators, as well as multinational and international terrorists, particularly as the close relationship between the OP agents and useful insecticides makes it easy to disguise the importation and purchase of small amounts of the precursors. Indeed, the use by Saddam Hussein of a nerve gas against the Kurds and his possible employment of the OP agents during his war with Iran, and the Sarin attack in the Tokyo underground by an extremist religious set magnetized the world with respect to the OP drugs. As these drugs exert their toxicity via their cholinergic action on the nervous, particularly central nervous, system, it is no wonder that the research in the cholinergic ? eld attracts, and merits, our intense attention. These considerations underlie the signi? cance of this book, as Alex Karczmar devotes an entire chapter of Exploring the Vertebrate Central Cholinergic Nervous System to anticholinest- ases (antiChEs), and as he is an acknowledged expert in the ? eld of cholinergic toxicity as well as a consultant to the Surgeon General of the U. S. Army.

Editors and Affiliations

  • Department of the Army, Washington, USA

    Alexander G. Karczmar

  • Department of Pharmacology and Experimental Therapeutics, Loyola University Medical Center, Maywood

    Alexander G. Karczmar

  • Edward J. Hines, Jr., VA Hospital, Hines, USA

    Alexander G. Karczmar

Bibliographic Information

  • Book Title: Exploring the Vertebrate Central Cholinergic Nervous System

  • Editors: Alexander G. Karczmar

  • DOI: https://doi.org/10.1007/978-0-387-46526-5

  • Publisher: Springer New York, NY

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer-Verlag US 2007

  • Hardcover ISBN: 978-0-387-28223-7Published: 04 October 2006

  • Softcover ISBN: 978-1-4899-7895-0Published: 23 August 2016

  • eBook ISBN: 978-0-387-46526-5Published: 05 April 2007

  • Edition Number: 1

  • Number of Pages: XIII, 698

  • Topics: Neurobiology, Neurosciences

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