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Influence of the preparation method on the physicochemical properties of econazole-β-cyclodextrin complexes

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Abstract

Econazole (C18H15Cl3N2O) is one of the common antifungal agents whose poor aqueous solubility restricts its use for the treatment of oropharyngeal candidiasis, which is the first symptom of HIV infection. Therefore, the aim of the current study was to investigate the effect of different preparation methods (i.e. kneading, coevaporation, sealed-heating, and supercritical carbon dioxide (SC CO2)) for obtaining solid inclusion complexes between β-cyclodextrin and econazole. The physico-chemical properties of the different products were characterized by differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FTIR) and powder X-ray diffractometry (PXRD). For the complexes prepared by the SC CO2 method, the effects of temperature and pressure have also been investigated and related to the solubility of econazole in SC CO2. Results suggested the validity of the SC CO2 method for preparing solid complexes between cyclodextrins and econazole, avoiding the use of organic solvents and problems of their complete removal. Moreover, temperature played a major role in promoting drug-carrier interactions, whereas pressure had limited effects.

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Acknowledgements

The authors are grateful to the Research Affairs at the United Arab Emirates University for the financial support of this project (contract no. 01-02-7-12/04) and to Ali Dowaidar and Baboucarr Jobe for their assistance with analysis of the samples.

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Authors and Affiliations

  1. Department of Chemical & Petroleum Engineering, UAE University, P.O. Box: 17555, Al-Ain, UAE

    Ali H. Al-Marzouqi & Ayser Solieman

  2. Department of Chemistry, UAE University, P.O. Box: 17555, Al-Ain, UAE

    Ihsan Shehadi

  3. Department of Pharmacology and Therapeutics, UAE University, P.O. Box: 17666, Al-Ain, UAE

    Abdu Adem

Authors
  1. Ali H. Al-Marzouqi
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  2. Ayser Solieman
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  3. Ihsan Shehadi
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  4. Abdu Adem
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Correspondence to Ali H. Al-Marzouqi.

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Al-Marzouqi, A.H., Solieman, A., Shehadi, I. et al. Influence of the preparation method on the physicochemical properties of econazole-β-cyclodextrin complexes. J Incl Phenom Macrocycl Chem 60, 85–93 (2008). https://doi.org/10.1007/s10847-007-9356-6

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  • DOI: https://doi.org/10.1007/s10847-007-9356-6

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