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Interleukin-1 cluster gene polymorphisms in childhood IgA nephropathy

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Abstract

We have carried out a study with the aim of investigating the association between single nucleotide polymorphisms (SNPs) of the IL-1 gene cluster and childhood IgA nephropathy (IgAN). SNPs of the IL-1α, IL-1β, and IL-1 receptor antagonist (RN) genes (IL1A, IL1B, and IL1RN, respectively) were analyzed in 182 patients with childhood IgAN and in 500 healthy controls. The IgAN patients were also dichotomized and compared with respect to proteinuria (<4 mg and ≥4 mg/m2 per hour, respectively), the presence or absence of podocyte foot process effacement, and the presence of pathologically early and advanced disease markers, such as interstitial fibrosis, tubular atrophy, or global sclerosis. Significant differences in SNP frequencies were observed for the IL1B and IL1RN genes (rs1143627, rs3917356, and rs1143633 in the IL1B gene, and rs928940, rs439154, and rs315951 in the IL1RN gene). Moreover, rs1143627, rs3917356, and rs1143633 of IL1B were found to be significantly associated with the presence of podocyte foot process effacement. Our results suggest that the IL1B and IL1RN genes are associated with increased susceptibility to IgAN in children. They also suggest that the development of proteinuria in IgAN is related to IL1A and that podocyte foot process effacement is associated with IL1B.

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Abbreviations

IgAN:

IgA nephropathy

IL1A:

interleukin-1α gene

IL1B:

interleukin-1β gene

IL1RN:

interleukin receptor antagonist gene

LD:

linkage disequilibrium

SNP:

single nucleotide polymorphism

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Acknowledgments

This research was supported by the Kyung Hee University Research Fund in 2006 (KHU-2006-1229).

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Authors and Affiliations

  1. Department of Pediatrics, East West Kidney Diseases Research Institute, School of Medicine, Kyung Hee University, Dondaemun-gu, Hoegi-dong #1, Seoul, 130-701, Korea

    Won Ho Hahn, Byoung Soo Cho & Sung Do Kim

  2. Kohwang Medical Research Institute, Kyung Hee University, Seoul, Korea

    Su Kang Kim & Sungwook Kang

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  1. Won Ho Hahn
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  2. Byoung Soo Cho
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Correspondence to Sung Do Kim.

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Hahn, W.H., Cho, B.S., Kim, S.D. et al. Interleukin-1 cluster gene polymorphisms in childhood IgA nephropathy. Pediatr Nephrol 24, 1329–1336 (2009). https://doi.org/10.1007/s00467-009-1146-5

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