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THE SHAPE OF MEDICINES TO COME: PHARMACEUTICALS IN THE 21ST CENTURY David J. Triggle OriginalPaper Pages: 315 - 324
CURRENT TRENDS IN DRUG DISCOVERY RESEARCH Stephen J. CutlerAnil Saxena OriginalPaper Pages: 313 - 314
Synthesis and Microbiological Evaluation of Novel [N-Acetyl-2,6-Diarylpiperidin-4-YL]-5-Spiro-4-Acetyl-2-(Acetylamino)-Δ2-1,3,4-Thiadiazolines S. BalasubramanianC. RamalinganS. Kabilan OriginalPaper Pages: 297 - 311
Design, Synthesis and Growth Inhibition Activity of Bis-Epoxyethyl Derivatives of Stallimycin Modified on the Amidino Moiety Romeo RomagnoliPier Giovanni BaraldiRoberto Gambari OriginalPaper Pages: 282 - 296
Development of Selective Ligands for Benzodiazepine Receptor Subtypes by Manipulating the Substituents at Positions 3- and 7- of Optically Active BzR Ligands Xiaoyan LiJianming YuJames M. Cook OriginalPaper Pages: 259 - 281
Synthesis and Cytotoxic Activity of 6-(Substituted-Phenyl)Amino-5,8-Quinazolinediones Chung-Kyu RyuYou-Jin YiChong-Ock Lee OriginalPaper Pages: 249 - 258
Drug Development in the 21st Century: Medicines, Man and Receptors David J Triggle OriginalPaper Pages: 238 - 248
Regulation of Xenobiotic Detoxification by Nuclear Receptors JM PascussiS Gerbal-ChaloinP Maurel OriginalPaper Pages: 228 - 237
Analogue-Based Drug Research: Lead and Drug Optimization Janos Fischer OriginalPaper Pages: 218 - 227
Identification of Ligands for the Orphan Nuclear Receptor GCNF Rogier BuijsmanAnja GarritsenPedro Hermkens OriginalPaper Pages: 210 - 215
Discovery of a New Family of Membrane Progesterone Receptors in Vertebrates and Detection of the Alpha and Beta Subtypes in Mouse Brain, Testis, and Uterus Peter Thomas OriginalPaper Pages: 202 - 209
(+)-Cyclazosin Derivatives as α1-Adrenoceptor Antagonists Gianni SagratiniMichela BuccioniDario Giardina OriginalPaper Pages: 190 - 199
Pharmacophore Development and 3D-QSAR Study of I1 Imidazoline Binding Site Ligands Orazio NicolottiAngelo CarottiMonique Dontenwill OriginalPaper 01 April 2004 Pages: 170 - 189
Alpha2-Adrenergic Receptors in Intestinal Epithelial Cells: Mechanisms of Signaling, Role, and Regulation Herve ParisChristelle CoattrieuxStephane Schaak OriginalPaper Pages: 158 - 169
The Design and Synthesis of a Novel, Orally Active, Selective ETA Antagonist David J. RawsonKevin N. DackDon Walker OriginalPaper Pages: 149 - 157
In Vitro and In Vivo Characterization of Alpha-1A Selective Agonists and Their Utility for Stress Incontience William A. CarrollRobert J. AltenbachJames P. Sullivan OriginalPaper Pages: 134 - 148
Cardiovascular and Urinary System Receptors: Focus on Endothelin Receptor and α1-Adrenoceptor Subtypes Rodolfo TestaAmedeo Leonardi OriginalPaper Pages: 131 - 133
Novel Mechanisms of Drug Action: Functional Selectivity at D2 Dopamine Receptors Richard B. MailmanElaine A. Gay OriginalPaper Pages: 115 - 126
Mechanisms and Issues Relating to the Use of D1-like Dopamine Receptor Agonists for Age-related Illnesses: Parkinson’s Disease and Memory and Cognition David E. NicholsMechelle M. Lewis OriginalPaper Pages: 105 - 114
Introduction to Receptors in Aging Diseases: GABA Receptors Wolfgang Froestl OriginalPaper Pages: 99 - 102
Potent, Selective Adenosine A1 Agonists as Potential Analgesics P.J. BeswickC. BountraD.J. Spalding OriginalPaper Pages: 88 - 98
Improgan-like Analgesics: A Family of Compounds Derived From Histamine Anatgonists L.B. HoughJ.W. NalwalkH. Timmerman OriginalPaper Pages: 78 - 87
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Monitoring Receptor Dimerisation Graeme MilliganGeraldine PascalJuan J. Carrillo OriginalPaper Pages: 18 - 24
The Nicotinic Acetylcholine Receptor: 25 Years Thereafter Ferdinand HuchoChristoph Weise OriginalPaper Pages: 11 - 17
Guest Editorial Gianfabio GiorgioniAlessandro PiergentiliRichard A. Glennon EditorialNotes Pages: 1 - 4
