1. Sleep substances, sleep architecture, and sleep sociology: Centennial anniversary of the first discovery of sleep substances by Kuniomi Ishimori

   • Yoshihiro Urade

   Preface 28 July 2016 Pages: 1 - 2

2. Humoral mechanisms of sleep–wake regulation: Historical review of prostaglandin D₂ and related substances

   • Osamu Hayaishi

   Review Article 28 July 2016 Pages: 3 - 9

3. Prostaglandin D2 and adenosine as endogenous somnogens

   • Yoshihiro Urade

   Review Article 28 July 2016 Pages: 10 - 17

4. Adenosine as a sleep factor

   • Tarja Porkka-Heiskanen
   • Anna V. Kalinchuk

   Review Article 28 July 2016 Pages: 18 - 23

5. Physiological and pathophysiological roles of adenosine

   • Bertil B. Fredholm

   Review Article 28 July 2016 Pages: 24 - 28

6. The ATP-cytokine-adenosine hypothesis: How the brain translates past activity into sleep

   • Parijat Sengupta
   • Sandip Roy
   • James M. Krueger

   Review Article 28 July 2016 Pages: 29 - 33

7. Key roles of the histaminergic system in sleep-wake regulation

   • Zhi-Li Huang
   • Yoshihiro Urade
   • Osamu Hayaishi

   Review Article 28 July 2016 Pages: 34 - 37

8. Interaction between sleep mechanisms and orexin neurons

   • Junko Hara
   • Takeshi Sakurai

   Review Article 28 July 2016 Pages: 38 - 43

9. Narcolepsy, orexins and respiratory regulation

   • Fang Han

   Review Article 28 July 2016 Pages: 44 - 51

10. Insomnia, hypersomnia and coma in animal models and their clinical implications

    • Kunio Kitahama
    • Pierre-Hervé Luppi

    Review Article 28 July 2016 Pages: 52 - 58

11. What are the mechanisms activating the sleep-active neurons located in the preoptic area?

    • Pierre-Hervé Luppi
    • Patrice Fort

    Review Article 28 July 2016 Pages: 59 - 64

12. Basal forebrain regulation of cortical activity and sleep-wake states: Roles of cholinergic and non-cholinergic neurons

    • Samüel Deurveilher
    • Kazue Semba

    Review Article 28 July 2016 Pages: 65 - 70

13. Sleep-active cells in the cerebral cortex and their role in slow-wave activity

    • Dmitry Gerashchenko
    • Jonathan P. Wisor
    • Thomas S. Kilduff

    Review Article 28 July 2016 Pages: 71 - 77

14. Genetic dissection of neural circuitry regulating behavioral state using conditional transgenics

    • Michael Lazarus
    • Clifford B. Saper
    • Patrick M. Fuller

    Review Article 28 July 2016 Pages: 78 - 83

15. Overview of sleep and sleep medicine in Asian countries

    • Yoan Cherasse

    Review Article 28 July 2016 Pages: 84 - 89