1. Limits of Neutral Drift: Lessons From the In Vitro Evolution of Two Ribozymes

   • Katherine L. Petrie
   • Gerald F. Joyce

   Original Article 26 August 2014 Pages: 75 - 90

   

2. Purine Biosynthetic Intermediate-Containing Ribose-Phosphate Polymers as Evolutionary Precursors to RNA

   • Harold S. Bernhardt
   • Roger K. Sandwick

   Original Article 02 September 2014 Pages: 91 - 104

   

3. General Trends in Selectively Driven Codon Usage Biases in the Domain Archaea

   • Andrés Iriarte
   • Eugenio Jara
   • Héctor Musto

   Short Review 20 September 2014 Pages: 105 - 110

   

4. Why Can’t Vertebrates Synthesize Trehalose?

   • Juan-Carlos Argüelles

   Review 18 September 2014 Pages: 111 - 116

   

5. One origin for metallo-β-lactamase activity, or two? An investigation assessing a diverse set of reconstructed ancestral sequences based on a sample of phylogenetic trees

   • Rosanna G. Alderson
   • Daniel Barker
   • John B. O. Mitchell

   Original Article Open access 04 September 2014 Pages: 117 - 129

   

6. Predicting Evolutionary Site Variability from Structure in Viral Proteins: Buriedness, Packing, Flexibility, and Design

   • Amir Shahmoradi
   • Dariya K. Sydykova
   • Claus O. Wilke

   Original Article 13 September 2014 Pages: 130 - 142

   

7. Essential is Not Irreplaceable: Fitness Dynamics of Experimental E. coli RNase P RNA Heterologous Replacement

   • Jasmine L. Loveland
   • Jocelyn Rice
   • Robert L. Dorit

   Original Article 30 September 2014 Pages: 143 - 152