1. Scientific and ethical concerns in clinical trials in Alzheimer's patients: the bridging study

   • N. R. Cutler
   • J. J. Sramek

   Special Article Pages: 421 - 428

2. Raised plasma levels of atrial natriuretic factor in cardiac allograft recipients: evidence of increased cardiac secretion and decreased renal clearance

   • C. C. Lang
   • T. Moreland
   • A. D. Struthers

   Pharmacodynamics Pages: 429 - 434

3. Effects of ACE inhibition on endurance exercise haemodynamics in trained subjects with mild hypertension

   • P. Palatini
   • S. Bongiovi
   • G. Raule

   Pharmacodynamics Pages: 435 - 439

4. Chronopharmacology of enalapril in hypertensive patients

   • K. Sunaga
   • A. Fujimura
   • A. Ebihara

   Pharmacodynamics Pages: 441 - 445

5. The cognitive and psychomotor effects of opioid analgesics

   • W. M. O'Neill
   • G. W. Hanks
   • K. Wesnes

   Pharmacodynamics Pages: 447 - 453

6. The cognitive and psychomotor effects of opioid analgesics

   • G. W. Hanks
   • W. M. O'Neill
   • K. Wesnes

   Pharmacodynamics Pages: 455 - 460

7. Comparative efficacy of hamamelis distillate and hydrocortisone cream in atopic eczema

   • H. C. Korting
   • M. Schäfer-Korting
   • P. Laux

   Clinical Trials Pages: 461 - 465

8. Pharmacological effects of concomitant administration of β-adrenoceptor blocker and agonist in normal subjects: characterization by heart rate response to exercise

   • M. Karita
   • H. Sato
   • M. Inoue

   Pharmacodynamics Pages: 467 - 471

9. Acute safety of the CFC-free propellant HFA-134a from a pressurized metered dose inhaler

   • D. Donnell
   • S. Ward
   • J. McEwen

   Pharmacodynamics Pages: 473 - 477

10. Variability of thiopental clearance in routine critical care patients

    • H. Russo
    • J. Brès
    • B. Roquefeuil

    Pharmacokinetics and Disposition Pages: 479 - 487

11. Serum kinetics, bioavailability and bone scanning of ^99mTc-labelled sodium olpadronate in patients with different rates of bone turnover

    • O. J. Degrossi
    • M. Ortiz
    • A. Pérez Lloret

    Pharmacokinetics and Disposition Pages: 489 - 494

12. Erythrocyte fraction affects red blood cell thiopurine methyltransferase activity

    • B. Klemetsdal
    • R. Lysaa
    • B. Straume

    Pharmacokinetics and Disposition Pages: 495 - 499

13. Lack of relationship between quinidine pharmacokinetics and the sparteine oxidation polymorphism

    • F. Nielsen
    • J. U. Rosholm
    • K. Brøsen

    Pharmacokinetics and Disposition Pages: 501 - 504

14. Comparison of the bioavailability of dexibuprofen administered alone or as part of racemic ibuprofen

    • B. Gabard
    • G. Nirnberger
    • J. M. Mayer

    Pharmacokinetics and Disposition Pages: 505 - 511

15. Anticholinergic antiparkinsonian therapy in outpatients treated with neuroleptic drugs: a prescription survey

    • S. Spila-Alegiani
    • F. Menniti-Ippolito
    • G. Diana

    Pharmacoepidemiology and Prescription Pages: 513 - 517

16. The pharmacokinetics of granisetron, a 5-HT₃ antagonist in healthy young and elderly volunteers

    • A. Allen
    • C. C. Davie
    • R. W. Jones

    Letter to the Editors Pages: 519 - 520

17. Announcements

    Announcement Pages: 521 - 522