1. Mutagenicity testing of pharmaceuticals: Present status

   • G. Zbinden

   OriginalPaper Pages: 1 - 7

2. Draft guidelines on mutagenicity testing of new drugs issued by the CPMP

   • Morrell H. Draper
   • John P. Griffin

   OriginalPaper Pages: 9 - 19

3. Evaluating the mutagenic potential of chemicals the minimal battery and extrapolation problems

   • F. H. Sobels

   OriginalPaper Pages: 21 - 30

4. Mutagenicity testing with Salmonella microsome test

   • H. Greim
   • W. Göggelmann
   • T. Wolff

   OriginalPaper Pages: 31 - 40

5. The fluctuation test

   • B. A. Bridges

   OriginalPaper Pages: 41 - 44

6. Appreciation of the value of different bacterial test systems for detecting and for ranking chemical mutagens

   • G. R. Mohn
   • J. Ellenberger

   OriginalPaper Pages: 45 - 60

7. Cytogenetical tests on mammalian cells in vitro

   • J. Moutschen

   OriginalPaper Pages: 61 - 75

8. Mutagenicity testing with Drosophila

   • Friedrich E. Würgler

   OriginalPaper Pages: 77 - 87

9. Mutagenicity test systems for the detection of chromosome aberrations in vivo

   • B. E. Matter
   • T. Tsuchimoto

   OriginalPaper Pages: 89 - 98

10. Mutagenicity testing with eukaryotic microorganisms

    • E. Moustacchi

    OriginalPaper Pages: 99 - 110

11. The place of the host-mediated assay

    • Douglas B. McGregor

    OriginalPaper Pages: 111 - 121

12. Induction of gene mutations in germ cells of the mouse

    • U. H. Ehling

    OriginalPaper Pages: 123 - 138

13. Unscheduled DNA synthesis in the testis, a secondary test for the evaluation of chemical mutagens

    • G. Zbinden

    OriginalPaper Pages: 139 - 149

14. Granuloma pouch assay for mutagenicity testing

    • P. Maier

    OriginalPaper Pages: 151 - 157

15. Inductest and spermatest in genetic toxicology testing

    • Maurice Hofnung
    • Nicole Weill

    OriginalPaper Pages: 159 - 169

16. Covalent binding of drug metabolites to DNA — a tool of predictive value?

    • Hermann M. Bolt
    • Reinhold J. Laib

    OriginalPaper Pages: 171 - 180

17. Metabolic activation of drugs in mutagenicity tests in vitro

    • M. B. Roberfroid

    OriginalPaper Pages: 181 - 193

18. International programme for the evaluation of short-term tests for carcinogenicity

    • I. F. H. Purchase
    • F. J. de Serres

    OriginalPaper Pages: 195 - 198