1. Importance of establishing the presence of drug active metabolites

   • Silvio Garattini

   Review Paper Pages: 97 - 108

2. Comparison of the plasma and urinary metabolites of [³H]-econazole nitrate in the monkey and pregnant and non-pregnant rat

   • R. Girkin
   • R. R. Brodie
   • L. F. Chasseaud

   Original Papers Pages: 109 - 116

3. Disposition and metabolism of [³H]gliclazide in rats

   • Hisashi Miyazaki
   • Toshihiko Fujii
   • Nanaya Tamaki

   Original Papers Pages: 117 - 131

4. Acetylation character of isoniazid in the rabbit and in man

   • M. F. Kergueris
   • Cl. Larousse
   • M. Bourin

   Original Papers Pages: 133 - 136

5. Pharmacokinetics and biotransformation of the prostacyclin analogue, ZK 36 374 I. Synthesis of a tritium marker and excretion of [³H]-ZK 36 374 in the rat

   • W. Krause
   • W. Skuballa
   • P. E. Schulze

   Original Papers Pages: 137 - 144

6. Pharmacokinetics and biotransformation of the prostacyclin analogue, ZK 36 374 II. Blood and plasma levels and passage of the blood/brain barrier in the rat

   • W. Krause
   • M. Schubert

   Original Papers Pages: 145 - 150

7. Enzymology of the metabolic pathway from nicotine to cotinine,in vitro

   • A. R. Hibberd
   • J. W. Gorrod

   Original Papers Pages: 151 - 162

8. Structural investigation of a new organic antiseptic: Taurolidine

   • F. Erb
   • M. Imbenotte
   • R. W. Pfirrmann

   Original Papers Pages: 163 - 173

9. Fluvoxamine maleate; Disposition in man

   • H. De Bree
   • J. B. Van Der Schoot
   • L. C. Post

   Original Papers Pages: 175 - 179

10. Differential consequences of renal failure on the pharmacokinetics of Oxprenolol and its main metabolite

    • P. Dayer
    • Ph. Glasson
    • J. Fabre

    Original Papers Pages: 181 - 188

11. Dose-dependent pharmacokinetics of sulpirideand sulpiride-induced prolactin secretionin man

    • F. R. Sugnaux
    • A. Benakis
    • R. Di Carlo

    Original Papers Pages: 189 - 200

12. New Books

    BookReview Pages: 201 - 202

13. Forthcoming papers

    Announcement Pages: 203 - 204

14. Event

    Announcement Pages: 205 - 205

15. EPA Symposium on SAFER CHEMICALS THROUGH MOLECULAR DESIGN Hyatt Regency, Arlington, Virgina — Sept. 11–15, 1983

    Announcement Pages: 205 - 206