Transcription of the insulin gene: towards defining the glucosesensitive cis-element and trans-acting factors D. MelloulE. Cerasi OriginalPaper Pages: S3 - S10
Glucose induces oscillatory Ca2+ signalling and insulin release in human pancreatic beta cells B. HellmanE. GylfeZ. Ling OriginalPaper Pages: S11 - S20
Regulation of insulin secretion: the role of second messengers S. L. HowellP. M. JonesS. J. Persaud OriginalPaper Pages: S30 - S35
Insulin secretory granule biogenesis and the proinsulin-processing endopeptidases J. C. Hutton OriginalPaper Pages: S48 - S56
Physiologic relevance of heterogeneity in the pancreatic beta-cell population D. PipeleersR. KiekensF. Schuit OriginalPaper Pages: S57 - S64
Proinsulin processing in the regulated and the constitutive secretory pathway P. A. Halban OriginalPaper Pages: S65 - S72
Does C-peptide have a physiological role? J. WahrenB. -L. JohanssonH. Wallberg-Henriksson OriginalPaper Pages: S99 - S107
Functional aspects of mouse islets transplanted to the kidney I. -B. TäljedalC. L. ShiP. Rooth OriginalPaper Pages: S112 - S116
Insulin receptor internalization: molecular mechanisms and physiopathological implications J. -L. Carpentier OriginalPaper Pages: S117 - S124
Signalling through the insulin receptor and the insulin-like growth factor-I receptor E. Van Obberghen OriginalPaper Pages: S125 - S134
The structural basis of insulin and insulin-like growth factor-I receptor binding and negative co-operativity, and its relevance to mitogenic versus metabolic signalling P. De Meyts OriginalPaper Pages: S135 - S148
Modulation of insulin receptor signalling: significance of altered receptor isoform patterns and mechanism of hyperglycaemia-induced receptor modulation H. U. HäringM. KellererL. Mosthaf OriginalPaper Pages: S149 - S154
Mechanisms modifying glucose oxidation in diabetes mellitus P. J. RandleD. A. PriestmanA. Halsall OriginalPaper Pages: S155 - S161
Central nervous system and peripheral abnormalities: clues to the understanding of obesity and NIDDM B. Jeanrenaud OriginalPaper Pages: S169 - S178
Recombinant human insulin-like growth factor-I: a therapeutic challenge for diabetes mellitus E. R. FroeschM. Hussain OriginalPaper Pages: S179 - S185