1. The solved and unsolved mysteries of the genetics of early-onset Alzheimer’s disease

   • Ekaterina Rogaeva

   Review Article Pages: 1 - 10

2. Autism

   • Janine A. Lamb
   • Jeremy R. Parr
   • Anthony P. Monaco

   Review Article Pages: 11 - 28

3. Adverse effect of a presenilin-1 mutation in microglia results in enhanced nitric oxide and inflammatory cytokine responses to immune challenge in the brain

   • Jaewon Lee
   • Sic L. Chan
   • Mark P. Mattson

   Original Research Pages: 29 - 45

4. DNA base-excision repair enzyme apurinic/apyrimidinic endonuclease/redox factor-1 is increased and competent in the brain and spinal cord of individuals with amyotrophic lateral sclerosis

   • Arif Y. Shaikh
   • Lee J. Martin

   Original Research Pages: 47 - 60

5. The actin-binding domain of spinophilin is necessary and sufficient for targeting to dendritic spines

   • Stacie D. Grossman
   • Linda C. Hsieh-Wilson
   • Paul Greengard

   Original Research Pages: 61 - 69

6. Methamphetamine-induced TNF-α gene expression and activation of AP-1 in discrete regions of mouse brain

   • Govinder Flora
   • Yong Woo Lee
   • Michal Toborek

   Original Research Pages: 71 - 85

7. Book review

   • Tobi Limke
   • Aiwu Cheng

   BookReview Pages: 87 - 88