1. The US Food and Drug Administration: A dysfunctional agency in need of major reforms

   • Steven E. Nissen

   Editor’s Commentary Pages: 167 - 169

2. Web Alert

   Announcement Pages: 170 - 171

3. Reversing heart failure: The Holy Grail

   • Monica Colvin-Adams

   Epidemiology and Pathophysiology of Heart Failure Pages: 175 - 177

4. Race-related differences in heart failure therapies: Simply black and white or shades of grey?

   • Gautam R. Shroff
   • Anne L. Taylor
   • Monica Colvin-Adams

   Epidemiology and Pathophysiology of Heart Failure Pages: 178 - 181

5. Safety and efficacy of nesiritide for acute decompensated heart failure: Recent literature and upcoming trials

   • Brian Hiestand
   • William T. Abraham

   Epidemiology and Pathophysiology of Heart Failure Pages: 182 - 186

6. Nesiritide for acute decompensated heart failure: Does the benefit justify the risk?

   • Jonathan Sackner-Bernstein
   • Keith D. Aaronson

   Epidemiology and Pathophysiology of Heart Failure Pages: 187 - 193

7. The financial burden of destination left ventricular assist device therapy: Who and when?

   • Mark C. Bieniarz
   • Reynolds Delgado

   Epidemiology and Pathophysiology of Heart Failure Pages: 194 - 199

8. Right ventricular failure complicating heart failure: Pathophysiology, significance, and management strategies

   • Mobusher Mahmud
   • Hunter C. Champion

   Epidemiology and Pathophysiology of Heart Failure Pages: 200 - 208

9. Predicting survival in heart failure

   • Viorel G. Florea
   • Inder S. Anand

   Epidemiology and Pathophysiology of Heart Failure Pages: 209 - 217

10. Sustained reversal of left ventricular remodeling following mechanical and pharmacologic therapy

    • Theo E. Meyer

    Management of Heart Failure Pages: 221 - 223

11. Diagnosis of diastolic heart failure

    • Hidekatsu Fukuta
    • William C. Little

    Management of Heart Failure Pages: 224 - 228

12. Prevalence and management of chronotropic incompetence in heart failure

    • Peter H. Brubaker
    • Dalane W. Kitzman

    Management of Heart Failure Pages: 229 - 235

13. Role of inflammation in the progression of heart failure

    • Arne Yndestad
    • Jan Kristian Damås
    • Pål Aukrust

    Management of Heart Failure Pages: 236 - 241

14. Glycemic control and treatment patterns in patients with heart failure

    • W. H. Wilson Tang

    Management of Heart Failure Pages: 242 - 247