An integrated modelling approach for targeted degradation: insights on optimization, data requirements and PKPD predictions from semi- or fully-mechanistic models and exact steady state solutions Sofia GuzzettiPablo Morentin Gutierrez Original Paper Open access 29 April 2023 Pages: 327 - 349
Population pharmacokinetic and pharmacokinetic-pharmacodynamic modeling of bempedoic acid and low-density lipoprotein cholesterol in healthy subjects and patients with dyslipidemia Satyawan B. JadhavBenny M. AmoreMaurice G. Emery Original paper Open access 27 May 2023 Pages: 351 - 364
Physiologically-based pharmacokinetic modeling to predict drug-drug interaction of enzalutamide with combined P-gp and CYP3A substrates Yukio OtsukaSrinivasu PoondruTsuyoshi Minematsu Original Paper Open access 21 June 2023 Pages: 365 - 376
Clinical validation of translational antibody PBPK model using tissue distribution data generated with 89Zr-immuno-PET imaging Shufang LiuZhe LiDhaval K. Shah Original Paper 29 June 2023 Pages: 377 - 394
A two-stages global sensitivity analysis by using the δ sensitivity index in presence of correlated inputs: application on a tumor growth inhibition model based on the dynamic energy budget theory Alessandro De CarloElena Maria ToscaPaolo Magni OriginalPaper Open access 09 July 2023 Pages: 395 - 409
Generation and application of avatars in pharmacometric modelling Estelle ChasseloupAndrew C. HookerMats O. Karlsson Original Paper Open access 24 July 2023 Pages: 411 - 423