1. Editorial

   • Thomas M. Ludden
   • Malcolm Rowland

   Editorial Introduction 01 December 1999 Pages: 557 - 558

2. Modeling Interactions between Adrenal Suppression and T-Helper Lymphocyte Trafficking during Multiple Dosing of Methylprednisolone

   • Fung-Sing Chow
   • Amarnath Sharma
   • William J. Jusko

   OriginalPaper 01 December 1999 Pages: 559 - 575

3. Sensitivity Analysis of Pharmacokinetic and Pharmacodynamic Systems: I. A Structural Approach to Sensitivity Analysis of Physiologically Based Pharmacokinetic Models

   • Ivan A. Nestorov

   OriginalPaper 01 December 1999 Pages: 577 - 596

4. Physiologically Based Pharmacokinetics of Cyclosporine A: Reevaluation of Dose–Nonlinear Kinetics in Rats

   • Chiaki Tanaka
   • Ryosei Kawai
   • Malcolm Rowland

   OriginalPaper 01 December 1999 Pages: 597 - 623

5. A Population Pharmacokinetic–Pharmacodynamic Analysis of Repeated Measures Time-to-Event Pharmacodynamic Responses: The Antiemetic Effect of Ondansetron

   • Eugène H. Cox
   • Christine Veyrat-Follet
   • Lewis B. Sheiner

   OriginalPaper 01 December 1999 Pages: 625 - 644

6. Announcements

   Announcement 01 December 1999 Pages: 645 - 646

7. Author Index for Volume 27

   Authors Index 01 December 1999 Pages: 647 - 648

8. Subject Index for Volume 27

   Subject Index 01 December 1999 Pages: 649 - 650