1. Modeling of delays in PKPD: classical approaches and a tutorial for delay differential equations

   • Gilbert Koch
   • Wojciech Krzyzanski
   • Johannes Schropp

   Original Paper 21 August 2014 Pages: 291 - 318

   

2. Enhancing population pharmacokinetic modeling efficiency and quality using an integrated workflow

   • Henning Schmidt
   • Andrijana Radivojevic

   Original Paper 24 July 2014 Pages: 319 - 334

   

3. Latent variable indirect response joint modeling of a continuous and a categorical clinical endpoint

   • Chuanpu Hu
   • Philippe O. Szapary
   • Honghui Zhou

   Original Paper 20 July 2014 Pages: 335 - 349

   

4. Predicting individual responses to pravastatin using a physiologically based kinetic model for plasma cholesterol concentrations

   • Niek C. A. van de Pas
   • Johan A. C. Rullmann
   • Albert A. de Graaf

   Original Paper 09 August 2014 Pages: 351 - 362

   

5. Population pharmacokinetic model to analyze nevirapine multiple-peaks profile after a single oral dose

   • Manuel Ibarra
   • Marta Vázquez
   • Pietro Fagiolino

   Original Paper 27 July 2014 Pages: 363 - 373

   

6. Incorporating target-mediated drug disposition in a minimal physiologically-based pharmacokinetic model for monoclonal antibodies

   • Yanguang Cao
   • William J. Jusko

   Original Paper 31 July 2014 Pages: 375 - 387