1. Looking forward into the next 25 years: the 25th anniversary issue of the Journal of Computer-Aided Molecular Design

   • Terry Richard Stouch

   Editorial 17 January 2012 Pages: 1 - 1

2. Limiting assumptions in structure-based design: binding entropy

   • Garland R. Marshall

   Perspective 03 January 2012 Pages: 3 - 8

   

3. Computational chemistry in 25 years

   • Ruben Abagyan

   Perspective 13 December 2011 Pages: 9 - 10

4. Computational chemistry in pharmaceutical research: at the crossroads

   • Jürgen Bajorath

   Perspective 15 November 2011 Pages: 11 - 12

5. A very short history of structure-based design: how did we get here and where do we need to go?

   • Jeff Blaney

   Perspective 11 December 2011 Pages: 13 - 14

6. The future of molecular dynamics simulations in drug discovery

   • David W. Borhani
   • David E. Shaw

   Perspective Open access 20 December 2011 Pages: 15 - 26

7. Democratization of computational chemistry and Chem(o)informatics

   • Frank K. Brown

   Perspective 29 December 2011 Pages: 27 - 28

8. Lions and tigers and bears, oh my! Three barriers to progress in computer-aided molecular design

   • Robert D. Clark
   • Marvin Waldman

   Perspective Open access 10 December 2011 Pages: 29 - 34

   

9. The inevitable QSAR renaissance

   • Richard D. Cramer

   Perspective Open access 30 November 2011 Pages: 35 - 38

10. The great descriptor melting pot: mixing descriptors for the common good of QSAR models

    • Yufeng J. Tseng
    • Anton J. Hopfinger
    • Emilio Xavier Esposito

    Perspective 27 December 2011 Pages: 39 - 43

11. Reflections on the past 25 years

    • Federico Gago

    Perspective 21 December 2011 Pages: 45 - 45

12. Computational chemistry and cheminformatics: an essay on the future

    • Robert Charles Glen

    Perspective 13 December 2011 Pages: 47 - 49

13. Computer-aided molecular design under the SWOTlight

    • Darren V. S. Green
    • Andrew R. Leach
    • Martha S. Head

    Perspective 15 December 2011 Pages: 51 - 56

    

14. Does your model weigh the same as a Duck?

    • Ajay N. Jain
    • Ann E. Cleves

    Perspective 21 December 2011 Pages: 57 - 67

    

15. Computation, experiment and molecular design

    • Peter W. Kenny

    Perspective 11 December 2011 Pages: 69 - 72

16. Darwinian Docking

    • Irwin D. Kuntz

    Perspective 06 December 2011 Pages: 73 - 75

17. Gazing into the crystal ball; the future of computer-aided drug design

    • Eric Martin
    • Peter Ertl
    • Richard Lewis

    Perspective 17 November 2011 Pages: 77 - 79

18. Molecular simulation methods in drug discovery: a prospective outlook

    • Xavier Barril
    • F. Javier Luque

    Perspective 08 December 2011 Pages: 81 - 86

19. Is there a future for computational chemistry in drug research?

    • Gerald M. Maggiora

    Perspective 19 November 2011 Pages: 87 - 90

20. Frozen out: molecular modeling in the age of cryocrystallography

    • Yvonne C. Martin
    • Steven W. Muchmore

    Perspective 24 December 2011 Pages: 91 - 92

21. Let’s get honest about sampling

    • David L. Mobley

    Perspective 24 November 2011 Pages: 93 - 95

22. Alpha shock

    • Mark A. Murcko
    • W. Patrick Walters

    Perspective Open access 04 January 2012 Pages: 97 - 102

23. The character of molecular modeling

    • Anthony Nicholls

    Perspective 17 December 2011 Pages: 103 - 105

24. Of possible cheminformatics futures

    • Tudor I. Oprea
    • Olivier Taboureau
    • Cristian G. Bologa

    Perspective 30 December 2011 Pages: 107 - 112

    

25. Some thoughts on the “A” in computer-aided molecular design

    • Matthias Rarey

    Perspective 13 December 2011 Pages: 113 - 114

    

26. Designing the molecular future

    • Gisbert Schneider

    Perspective 30 November 2011 Pages: 115 - 120

    

27. Can we really do computer-aided drug design?

    • Matthew Segall

    Perspective 11 December 2011 Pages: 121 - 124

    

28. The errors of our ways: taking account of error in computer-aided drug design to build confidence intervals for our next 25 years

    • Terry Richard Stouch

    Perspective 14 January 2012 Pages: 125 - 134

29. The perspectives of computational chemistry modeling

    • Igor V. Tetko

    Perspective 11 December 2011 Pages: 135 - 136

30. Drug design for ever, from hype to hope

    • G. Seddon
    • V. Lounnas
    • G. Vriend

    Perspective Open access 18 January 2012 Pages: 137 - 150

    

31. Silver threads

    • Wendy A. Warr

    Perspective 09 December 2011 Pages: 151 - 152

32. The Journal of Computer-Aided Molecular Design: a bibliometric note

    • Peter Willett

    Perspective 16 November 2011 Pages: 153 - 157

33. If we designed airplanes like we design drugs…

    • Walter S. Woltosz

    Perspective Open access 03 December 2011 Pages: 159 - 163