1. Molecular and Physiologic Mechanisms of Drug Resistance in Cancer: An Overview

   • R.S. Kerbel

   Editorial Introduction Pages: 1 - 2

2. Drug Resistance in Melanoma: Mechanisms, Apoptosis, and New Potential Therapeutic Targets

   • Douglas Grossman
   • Dario C. Altieri

   OriginalPaper Pages: 3 - 11

3. Multidrug Resistance in Brain Tumors: Roles of the Blood–brain Barrier

   • Anthony Régina
   • Michel Demeule
   • Richard Béliveau

   OriginalPaper Pages: 13 - 25

4. Lineage-specific Mechanism of Drug and Radiation Resistance in Melanoma Mediated by Tyrosinase-related Protein 2

   • Brian J. Pak
   • Wendy Chu
   • Yaacov Ben-David

   OriginalPaper Pages: 27 - 32

5. Translational Regulation as a Novel Mechanism for the Development of Cellular Drug Resistance

   • John C. Schmitz
   • Jun Liu
   • Edward Chu

   OriginalPaper Pages: 33 - 41

6. Mechanisms Associated with cell Adhesion Mediated Drug Resistance (CAM-DR) in Hematopoietic Malignancies

   • Lori A. Hazlehurst
   • William S. Dalton

   OriginalPaper Pages: 43 - 50

7. Death Receptor Ligands, in Particular TRAIL, to Overcome Drug Resistance

   • S. de Jong
   • T. Timmer
   • E.G.E. de Vries

   OriginalPaper Pages: 51 - 56

8. Intermittent Blood Flow in Solid Tumours – an under-appreciated Source of ‘drug Resistance’

   • Ralph E. Durand

   OriginalPaper Pages: 57 - 61

9. Drug Resistance in Cancer: A Perspective

   • James H. Goldie

   OriginalPaper Pages: 63 - 68

10. Resistance to Rapamycin: A Novel Anticancer Drug

    • Shile Huang
    • Peter J. Houghton

    OriginalPaper Pages: 69 - 78

11. Possible Mechanisms of Acquired Resistance to Anti-angiogenic Drugs: Implications for the Use of Combination Therapy Approaches

    • Robert S. Kerbel
    • Joanne Yu
    • Janusz Rak

    OriginalPaper Pages: 79 - 86

12. The Role for Liposomal Drug Delivery in Molecular and Pharmacological Strategies to Overcome Multidrug Resistance

    • Lawrence D. Mayer
    • Jennifer A. Shabbits

    OriginalPaper Pages: 87 - 93

13. Prospects for Targeting Protein Kinase C Isozymes in the Therapy of Drug-resistant Cancer – An Evolving Story

    • Catherine A. O'Brian
    • Nancy E. Ward
    • Feng Chu

    OriginalPaper Pages: 95 - 100

14. Adjuvant Treatment of Colorectal Cancer: Towards Tumor-specific Immunotherapies

    • AJM van den Eertwegh
    • A Baars
    • HM Pinedo

    OriginalPaper Pages: 101 - 108

15. Targeting Molecular Signals in Chk1 Pathways as a New Approach for Overcoming Drug Resistance

    • Gunnar Hapke
    • Ming-biao Yin
    • Youcef M. Rustum

    OriginalPaper Pages: 109 - 115

16. The Challenge of Pathway and Environment-mediated Drug Resistance

    • Edward A. Sausville

    OriginalPaper Pages: 117 - 122

17. Tumor Physiology and Drug Resistance

    • Ian F. Tannock

    OriginalPaper Pages: 123 - 132

18. Malignant Cells, Directors of the Malignant Process: Role of Transforming Growth Factor-beta

    • Beverly A. Teicher

    OriginalPaper Pages: 133 - 143

19. Instructions for Authors

    Instructions for Authors Pages: 145 - 145