Abstract
Orbital tumor is a rare presentation of lymphoma. Unspecific symptoms, local infiltration, chronic progression may mimic other more common orbital diseases and often make the diagnosis difficult. We report a case of orbital non-Hodgkin lymphoma initially diagnosed as Graves’ disease. A 65-year-old woman was admitted to the Department of Endocrinology with a diagnosis of a left eye tumor. On admission, apart from the tumor, exophthalmos and the upper eyelid proptosis were present. The lesion had been observed for two years before hospitalization. Due to the muscle infiltration, as detected on computed tomography scanning and magnetic resonance imaging, Graves’ disease was suggested. The thyroid function was normal. Further diagnosis performed during hospitalization revealed lymphoplasmacytic lymphoma. Lymphoma may manifest as a localized orbital tumor without extraorbital or constitutive symptoms. Rare orbital diseases, among others lymphoproliferations, should be taken into account in the differential diagnosis of exophthalmos.
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Fedor R., Skorin R., Malignant lymphoma of the orbit. A case report, Optometry today,2005,http://www.optometry.myzen.co.uk/articles/docs/dd8d10f44977a672b9942f0322dbb5a7_fedor20050715.pdf
Bednaruk-Mlynski E., Czupryn A., Jassem J., MALTtype orbital lymphoma: a case report and the review of the literature, Onkologia w Praktyce Klinicznej, 2007, 1, 32–35
Decaudin D., de Cremoux P., Vincent-Salomon A., Dendale R., Lumbroso-Le Ruic., Ocular adnexal lymphoma: a review of clinicopathologic features and treatment options, Blood, 2006, 108, 1451–1460
Rey-Porca C., Perez-Encinas M., Gonzalez F., Orbital lymphomas. Presentation of nine cases, Arch. Soc. Esp. Oftalmol., 2008, 83, 95–104
Schick U., Lermen O., Unsold R., Hassler W., Treatment of primary orbital lymphomas, Eur. J. Haematol., 2004, 72, 186–192
Narayanan G., Ratheesan K., Madhavan J., Rajan B., Primary orbital lymphoma — A review of 25 cases from India, Journal of Clinical Oncology, 2004, Supplement, 6721
Nutting C.M., Jenkins C.D., Norton A.J., Cree I., Rose G.E., Plowman P.N., Primary orbital lymphoma, The Hematology Journal, 2002, 3, 14–16
Terpos E., Theocharis S., Panitsas F., Revelos K., Tsionos K., Karkantaris C:., Anaplastic primary orbital lymphoma: report of a case and review of the literature, Haema., 2002, 7, 370–373
Rosado M.F., Byrne G.E., Ding F., Fields K.A., Ruiz P., Dubovy S.R., et al., Ocular adnexal lymphoma: a clinicopathologic study of a large cohort of patients with no evidence for an association with Chlamydia psittaci, Blood, 2006,107, 467–472
Lagoo A.S., Haggerty C., Kim Y., Hammons M., Neufeld K., Redher C., et al., Morphologic features of 115 lymphomas of the orbit and ocular adnexa categorized according to the World Health Organization classification: are marginal zone lymphomas in the orbit mucosa-associated lymphoid tissue-type lymphomas?, Arch. Pathol. Lab. Med., 2008, 132, 1405–1416
Demirci H., Shields C.L., Karatza E.C., Shields J.A., Orbital lymphoproliferative tumors analysis of clinical features and systemic involvement in 160 cases, Ophthalmology, 2008, 115, 1626–1631
Lowen M.S., Saraiva V.S., Martins M.C., Burnier Jr. M.N., Immuohistochemical profile of lymphoid lesions of the orbit, Can. J. Ophthalmol., 2005, 40, 634–639
Brisbane J.U., Lessell S., Finkel H.E., Neiman R.S., Malignant lymphoma presenting in the orbit: A clinicopathologic Study of Rare Immunoglobulin-Producing Variant, Cancer, 1981, 47, 548–553
Coupland S.E., Hummel M., Stein H., Ocular adnexal lymphomas: five case presentations and a review of the literature, Surv. Ophtalmol., 2002, 47, 470–490
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Wolyniak, B., Lewczuk, A., Obolonczyk, L. et al. Orbital lymphoma mimicking Graves’ ophthalmopathy: a case report. cent.eur.j.med 6, 826–829 (2011). https://doi.org/10.2478/s11536-011-0081-6
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DOI: https://doi.org/10.2478/s11536-011-0081-6