References
Genentech. FDA grants accelerated approval of Avastin for brain cancer (glioblastoma) that has progressed following prior therapy [online]. Available from URL: http://www.gene.com/gene/news/press-releases/display.do?method=detail&id=12087 [Accessed 2009 Nov 20]
Lai A, Tran A, Nghiemphu PL, et al. Phase II study of bevacizumab plus temozolomide during and after radiation therapy for patients with newly diagnosed glioblastoma multiforme. J Clin Oncol 2010; 29(2): 142–8
Vredenburgh JJ, Desjardins A, Reardon DA, et al. The addition of bevacizumab to standard radiation therapy and temozolomide followed by bevacizumab, temozolomide and irinotecan for newly diagnosed glioblastoma. Cancer Res 2011; 17(12): 4119–24
Folkman J. What is the evidence that tumors are angiogenesis dependent? J Natl Cancer Inst 1990; 82: 4–6
Ferrara N, Gerber HP, LeCouter J. The biology of VEGF and its receptors. Nat Med 2003; 9: 669–76
Morabito A, De Maio E, Di Maio M, et al. Tyrosine kinase inhibitors of vascular endothelial growth factor receptors in clinical trials: current status and future directions. Oncologist 2006; 11: 753–64
Carmeliet P, Jain RK. Angiogenesis in cancer and other diseases. Nature 2000; 407: 249–57
Chamberlain MC. Emerging clinical principles on the use of bevacizumab in the treatment of malignant gliomas. Cancer 2010; 116(17): 3988–99
Takano S, Yoshii Y, Kondo S, et al. Concentration of vascular endothelial growth factor in the serum and tumor tissue of brain tumor patients. Cancer Res 1996; 56: 2185–90
Chi A, Norden AD, Wen PY. Inhibition of angiogenesis and invasion in malignant gliomas. Expert Rev Anticancer Ther 2007; 7: 1537–60
Sathornsumetee S, Rich JN. Antiangiogenic therapy in malignant glioma: promise and challenge. Curr Pharm Des 2007; 13: 3545–58
Friedman HS, Prados MD, Wen PY, et al. Bevacizumab alone and in combination with irinotecan in recurrent glioblastoma. J Clin Oncol 2009; 27: 4733–40
Kreisl TN, Kim L, Moore K, et al. Phase II trial of single-agent bevacizumab followed by bevacizumab plus irinotecan at tumor progression in recurrent glioblastoma. J Clin Oncol 2009; 27: 740–5
Raizer JJ, Grimm S, Chamberlain MC, et al. A phase II trial of single agent bevacizumab given in an every 3-week schedule for patients with recurrent high-grade gliomas. Cancer 2010; 116(22): 5297–305
Stark-Vance V. Bevacizumab and CPT-11 in the treatment of relapsed malignant glioma [abstract]. Neuro Oncol 2005; 7(3): 369
Wick W, Puduvalli VK, Chamberlain MC, et al. Phase III study of enzastaurin compared with lomustine in the treatment of recurrent intracranial glioblastoma. J Clin Oncol 2010; 28: 1168–74
Batchelor TT, Mulholland P, Neyns B, et al. The efficacy of cediranib as monotherapy and in combination with lomustine alone in patients with recurrent glioblastoma: a phase III randomized study. Neuro Oncol 2010; 12 Suppl. 4: iv69–78
Grossman SA, Ye X, Piantadosi S, et al. Survival of patients with newly diagnosed glioblastoma treated with radiation and temozolomide in research studies in the United States. Clin Cancer Res 2010; 16(8): 2443–9
Gilbert M. RTOG 0525: a randomized phase III trial comparing standard adjuvant temozolomide with a dose dense schedule in newly diagnosed glioblastoma [abstract no. 2006]. J Clin Oncol 2011; 29(15S): 141s
Chinot O. AVAglio: a phase III trial of bevacizumab added to standard radiotherapy and temozolomide in patients with newly diagnosed glioblastoma [abstract no. TPS 136]. J Clin Oncol 2011; 29(15S): 16s
Levin VA, Bidaut L, Hou P, et al. Randomized double-blind placebo-controlled trial of bevacizumab therapy for radiation necrosis of the central nervous system. Int J Radiat Oncol Biol Phys 2011 Apr 1; 79(5): 1487–95
Nghiemphu PL, Liu W, Lee Y, et al. Bevacizumab and chemotherapy for recurrent glioblastoma: a single-institution experience. Neurology 2009; 72(14): 1217–22
Stupp R, Mason WP, van den Bent MJ, et al. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med 2005; 352: 987–96
Acknowledgements
The editorial assistance of Sharon Larsson is appreciated and recognized. The author serves on the advisory board and speaker’s bureau for Genentech/Roche; however, no funding or support was provided for the preparation of this manuscript.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Chamberlain, M.C. Treatment of Glioblastoma with Bevacizumab. CNS Drugs 25, 815–818 (2011). https://doi.org/10.2165/11587880-000000000-00000
Published:
Issue Date:
DOI: https://doi.org/10.2165/11587880-000000000-00000