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Management of Chronic Daily Headache in Children and Adolescents

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Abstract

Chronic daily headache (CDH) occurs in 1–2% of children and adolescents. It can evolve from either episodic tension-type headache or episodic migraine, or can appear with no previous headache history. As with other primary headache disorders, treatment is based on the level of disability. There are children and adolescents who cope well, but there are others who are markedly disabled by their chronic headaches. As in adults, children and adolescents with CDH are at risk for medication overuse.

CDH is a diagnosis of exclusion, based on a thorough history, normal physical examination, and negative neuroimaging findings. Along with the chronic headaches, children with this condition may have co-morbid sleep problems, autonomic dysfunction, anxiety, and/or depression. Principles of treatment include identifying migrainous components, stopping medication overuse, stressing normalcy, using rational pharmacotherapy, and addressing co-morbid conditions. Successful outcomes often involve identifying an appropriate headache preventative, reintegration into school, and family participation in resetting realistic expectations.

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References

  1. International Headache Society. International classification of headache disorders (ICHD-II). Cephalalgia 2004; 24(Suppl. 1) 23–136

    Google Scholar 

  2. Wang SJ, Fuh JL, Lu SR, et al. Chronic daily headache in adolescents: prevalence, impact, and medication overuse. Neurology 2006; 66: 193–7

    Article  PubMed  Google Scholar 

  3. Kavuk I, Yavuz A, Cetindere U, et al. Epidemiology of chronic daily headache. Eur J Med Res 2003; 8: 236–40

    PubMed  CAS  Google Scholar 

  4. Gladstein J, Holden EW, Peralta L, et al. Diagnoses and symptom patterns in children presenting to a Pediatric headache clinic. Headache 1993; 33: 497–500

    Article  PubMed  CAS  Google Scholar 

  5. Hershey AD, Powers SW, Bentti AL, et al. Characterization of chronic daily headaches in children in a multidisciplinary headache center. Neurology 2001; 56: 1032–7

    Article  PubMed  CAS  Google Scholar 

  6. Silberstein SD, Lipton RB, Solomon S, et al. Classification of daily and near-daily headaches: proposed revisions to the IHS criteria. Headache 1994; 34: 1–7

    Article  Google Scholar 

  7. Silberstein SD, Lipton RB, Sliwinski M. Classification of daily and near-daily headaches: field trial of revised IHS criteria. Neurology 1996; 47: 871–5

    Article  PubMed  CAS  Google Scholar 

  8. Mack KJ. What incites new daily persistent headache in children? Pediatr Neurol 2004; 1: 122–5

    Article  Google Scholar 

  9. Gladstein J, Holden EW. Chronic daily headache in children and adolescents: a 2-year prospective study. Headache 1996; 36: 349–51

    Article  PubMed  CAS  Google Scholar 

  10. Koenig MA, Gladstein J, McCarter RJ, et al. Pediatric Committee of the American Headache Society. Chronic daily headache in children and adolescents presenting to tertiary headache clinics. Headache 2002 Jun; 42(6): 491–500

    Article  PubMed  Google Scholar 

  11. Howard L, Wessely S, Leese M, et al. Are investigations anxiolytic or anxiogenic? A randomized controlled trial of neuroimaging to provide reassurance in chronic daily headace. J Neurol Neurosurg Psychiatry 2005; 76(11): 1558–64

    Article  PubMed  CAS  Google Scholar 

  12. Practice parameter: the utility of neuroimaging in the evaluation of headache in patients with normal neurologic examinations (summary statement). Report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology 1994; 44: 1353–4

  13. Schwedt TJ, Guo Y, Rothner AD. “Benign” imaging abnormalities in children and adolescents with headache. Headache 2006; 46: 387–98

    Article  PubMed  Google Scholar 

  14. Hershey AD, Powers SW, Vockell AL, et al. PedMIDAS: development of a questionnaire to assess disability of migraines in children. Neurology 2001; 57: 2034–9

    Article  PubMed  CAS  Google Scholar 

  15. Mathew NT, Kurman R, Perez F. Drug induced refractory headache: clinical features and management. Headache 1990; 30: 634–8

    Article  PubMed  CAS  Google Scholar 

  16. Maizels M, Burchette R. Somatic symptoms in headache patients: the influence of headache diagnosis, frequency, and co morbidity. Headache 2004; 44: 983–93

    Article  PubMed  Google Scholar 

  17. Thieben MJ, Sandroni P, Sletten DM, et al. Postural orthostatic tachycardia syndrome: the Mayo Clinic experience. Mayo Clin Proc 2007; 82(3): 308–13

    PubMed  CAS  Google Scholar 

  18. Silberstein SD, Liu D. Drug overuse and rebound headache. Curr Pain Headache Rep 2002; 6: 240–7

    Article  PubMed  Google Scholar 

  19. Relja G, Granato A, Bratina A, et al. Outcome of medication overuse headache after abrupt in-patient withdrawal. Cephalalgia 2006 May; 26(5): 589–95

    Article  PubMed  CAS  Google Scholar 

  20. Raskin NH. Repetitive intravenous ergotamine therapy for the treatment of intractable migraine. Neurology 1986; 36: 995–7

    Article  PubMed  CAS  Google Scholar 

  21. Mathew NT, Kailasam J, Meadors L, et al. Intravenous valproate sodium (depacon) aborts migraine rapidly: a preliminary report. Headache 2000; 40: 720–3

    Article  PubMed  CAS  Google Scholar 

  22. Krymchantowski AV, Barbosa JS. Dexamethasone decreases migraine recurrence observed after treatment with a triptan combined with a nonsteroidal anti-inflammatory drug. Arq Neuropsiquiatr 2001; 59: 708–11

    Article  PubMed  CAS  Google Scholar 

  23. Lewis D, Ashwal S, Hershey A, et al. American Academy of Neurology Quality Standards Subcommittee; Practice Committee of the Child Neurology Society. Practice parameter: pharmacological treatment of migraine headache in children and adolescents: report of the American Academy of Neurology Quality Standards Subcommittee and the Practice Committee of the Child Neurology Society. Neurology 2004; 63: 2215–24

    Article  PubMed  CAS  Google Scholar 

  24. Linde K, Rossnagel K. Propanolol for migraine prophylaxis. Cochrane Database Syst Rev 2004; 2: CD003225

    Google Scholar 

  25. Swanson JW. Topiramate for migraine prevention. Curr Neurol Neurosci Rep 2005; 5: 77–8

    Article  PubMed  Google Scholar 

  26. Borzy JC, Koch TK, Schimschock JR. Effectiveness of topimarate in the treatment of Pediatric chronic daily headache. Pediatr Neurol 2005; 33(5): 314–6

    Article  PubMed  Google Scholar 

  27. Comer SD, Haney M, Fischman MW, et al. Cyproheptadine produced modest increases in total caloric intake by humans. Physiol Behav 1997; 62: 831–9

    Article  PubMed  CAS  Google Scholar 

  28. Colombo B, Annovazzi PO, Comi G. Therapy of primary headaches: the role of antidepressants. Neurol Sci 2004; 25Suppl. 3: S171–5

    Article  PubMed  Google Scholar 

  29. Chronicle E, Mulleners W. Anticonvulsant drugs for migraine prophylaxis. Cochrane Database Syst Rev 2004; 3: CD003226

    Google Scholar 

  30. Fava M. Psychopharmacologic treatment of pathologic aggression. Psychiatr Clin North Am 1997; 20: 427–51

    Article  PubMed  CAS  Google Scholar 

  31. Gherpelli JL, Esposito SB. A prospective randomized double blind placebo controlled crossover study of fluoxetine efficacy in the prophylaxis of chronic daily headache in children and adolescents. Arq Neuropsiquiatr 2005; 63: 559–63

    Article  PubMed  Google Scholar 

  32. Adelman LC, Adelman JU, VonSeggern R, et al. Venlafaxine extended release (XR) for the prophylaxis of migraine and tension-type headache: a retrospective study in a clinical setting. Headache 2000; 40: 572–80

    Article  PubMed  CAS  Google Scholar 

  33. Bianchi A, Salomone S, Caraci F, et al. Role of magnesium, coenzymeQ10, riboflavin, and vitamin B12 in migraine prophylaxis. Vitam Horm 2004; 69: 297–312

    Article  PubMed  CAS  Google Scholar 

  34. Dodick DW, Mauskop A, Elkind AH, et al. Botulinum toxin type a for the prophylaxis of chronic daily headache: subgroup analysis of patients not receiving other prophylactic medications: a randomized double-blind, placebo-controlled study. Headache 2005; 45: 315–24

    Article  PubMed  Google Scholar 

  35. Penzien DB, Rains JC, Andrasik F. Behavioral management of recurrent headache: three decades of experience and empiricism. Appl Psychophysiol Biofeedback 2002; 27: 163–81

    Article  PubMed  Google Scholar 

  36. Hershey AD, Powers SW, Bentti AL, et al. Effectiveness of amitriptyline in the prophylactic management of childhood headaches. Headache 2000; 40: 539–49

    Article  PubMed  CAS  Google Scholar 

  37. Galli F, Patron L, Russo PM, et al. Chronic daily headache in childhood and adolescence: clinical aspects and a 4-year follow-up. Cephalalgia 2004; 24: 850–8

    Article  PubMed  CAS  Google Scholar 

Download references

Acknowledgments

No sources of funding were used to assist in the preparation of this review. Jack Gladstein is on the Speakers Bureau for GlaxoSmithKline, Pfizer and AstraZeneca.

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Correspondence to Kenneth J. Mack.

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Mack, K.J., Gladstein, J. Management of Chronic Daily Headache in Children and Adolescents. Pediatr-Drugs 10, 23–29 (2008). https://doi.org/10.2165/00148581-200810010-00003

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