Abstract
Summary
Recurrent brief depression (RBD) fulfils DSM-IV criteria for major depression, with the exception of the duration of the depressive episodes. Recent epidemiological studies have confirmed the existence of RBD and estimated that it has a high prevalence in the general population and in general practice (approximately 10%). These studies also indicate a high comorbidity of RBD with attempted suicide, other forms of depression, anxiety disorders and substance abuse.
At present, data on the treatment of this disorder are sparse. Results from the few preliminary treatment studies that have been performed to date do not indicate that antidepressants are the treatment of choice. However, the mechanism of action and appropriate dosage of antidepressants in this disorder and the influence of comorbid disorders on treatment response have not yet been addressed sufficiently. Studies in carefully selected patient samples with RBD using various pharmacological approaches are required to further clarify which drugs might be specifically effective in this disorder.
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References
Angst J. The history and concept of recurrent brief depression. Eur Arch Psychiatry Clin Neurosci 1994; 244: 171–3
Pohl E. Die Melancholie nach dem neuesten Standpunkte der Physiologie und aufGrundlage k1inischer Beobachtungen. Prague: Verlag JG Calve’schen Buchhandlung, 1852
Head H. Certain mental changes that accompany visceral disease. Brain 1901; 24: 345–429
Gregory MS. Transient attacks of manic-depressive insanity. Med Rec 1915; 88: 1040–4
Paskind HA. Brief attacks of manic-depressive depression. Arch Neurol Psychiatry (Chicago) 1929; 22: 123–34
Busse EW, Barnes RH, Silverman AJ, et al. Studies of the processes of aging, X: the strengths and weaknesses of psychic functioning in the aged. Am J Psychiatry 1955; 111: 896–90I
Clayton PJ, Marten S, Davis MA, et al. Mood disorder in women professionals. J Affect Disord 1980; 2: 37–46
Montgomery SA, Roy D, Montgomery DB. The prevention of recurrent suicidal acts. Br J Clin Pharmacol 1983; 15: 183S–8S
Montgomery SA, Montgomery D, Baldwin D, et al. Intermittent 3-day depressions and suicidal behaviour. Neuropsychobiology 1989; 22: 128–34
Montgomery SA, Montgomery D, Baldwin D, et al. The duration, nature and recurrence rate of brief depressions. Prog Neuropsych Bioi Psychiatry 1990; 14: 729–35
Angst J, Dobler-Mikola A. The Zurich Study. II. The continuum from normal to pathological depressive mood swings. Eur Arch Psychiatry Neurol Sci 1984; 234: 21–9
Angst J, Dobler-Mikola A. The Zurich Study. A prospective epidemiological study of depressive, neurotic and psychosomatic syndromes. IV. Recurrent and nonrecurrent brief depression. Eur Arch Psychiatry Neurol Sci 1985; 235: 408–16
Angst J, Merikangas KR, Scheidegger P, et al. Recurrent brief depression: a new subtype of affective disorder. J Affect Disord 1990; 19: 87–98
Kasper S, Ruhrmann S, Haase T, et al. Recurrent brief depression and its relationship to seasonal affective disorder. Eur Arch Psychiatry Clin Neurosci 1992; 242: 20–6
Kasper S, Ruhrmann S, Haase T, et al. Evidence for a seasonal form of recurrent brief depression (RBD-seasonal). Eur Arch Psychiatry Clin Neurosci 1994; 244: 205–10
World Health Organization. The ICD-10 classification of mental and behavioural disorders. Clinical descriptions and diagnostic guidelines Geneva: World Health Organization, 1992
American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 4th ed. Washington, DC: American Psychiatric Association, 1994
Weiller E, Boyer P, Lepine J-P, et al. Prevalence of recurrent brief depression in primary care. Eur Arch Psychiatry Clin Neurosci 1994; 244: 174–81
Weiller E, Lecrubier Y, Maier W, et al. The relevance of recurrent brief depression in primary care. A report from the WHO project on psychological problems in general health care conducted in 14 countries. Eur Arch Psychiatry Clin Neurosci 1994; 244: 182–9
Maier W, Herr R, Gansicke M, et al. Recurrent brief depression in general practice. Clinical features, comorbidity with other disorders and need for treatment. Eur Arch Psychiatry C1in Neurosci 1994; 244: 196–204
Maier W, Herr R, Lichtermann D, et al. Brief depression among patients in general practice. Prevalence and variation by recurrence and severity. Eur Arch Psychiatry Clin Neurosci 1994; 244: 190–5
Montgomery SA, Montgomery D, McAuley R, et al. Maintenance therapy in repeat suicidal behaviour: a placebo controlled trial. Proceedings of the 10th International Congress for Suicide Prevention and Crisis Intervention; 1979 Jun 19; Ottawa, 227–9
Montgomery SA, Montgomery DB, Evans R. Pharmacological differences between brief and major depressions. Eur Neuropsychopharrnaco1 1993; 3 Suppl.3: 214–5
Montgomery DB, Roberts A, Green M, et al. Lack of efficacy of fluoxetine in recurrent brief depression and suicidal attempts. Eur Arch Psychiatry Clin Neurosci 1994; 244: 211–5
American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 3rd ed. rev. Washington, DC: American Psychiatric Association, 1987
Rosenthal NE, Sack DA, Gillin JC, et al. Seasonal affective disorder, a description of the syndrome and preliminary findings with light therapy. Arch Gen Psychiatry 1984; 41: 72–80
Montgomery SA, Asberg M. A new depression scale designed to be sensitive to change. Br J Psychiatry 1979; 134: 382–9
Teicher MH, Glod C, Cole JO. Emergence of intense suicidal preoccupation during fluoxetine treatment. Am J Psychiatry 1990; 147: 207–10
Kasper S, Fuger J, Moller HJ. Comparative efficacy of antidepressants. Drugs 1992; 43 Suppl.2: 11–23
Kasper S, Schindler S, Neumeister A. Le risque de suicide dans 1a depression et ses implications pour Ie traitement psychopharmacologique. Neuro-psy 1994 (numero special - Dec): 46–55
Staner L, De La Fuente JM, Kerkhofs M, et al. Biological and clinical features of recurrent brief depression: a comparison with major depressed and healthy subjects. J Affect Disord 1992; 26: 241–6
Thies-Flechtner K, Seibert W, Walther A, et al. Suizide bei rezidivprophylaktisch behandelten Patienten mit affektiven Psychosen. In: Miiller-Oerlinghausen B, Berghofer A, editors. Ziele und Ergebnisse der medikamentOsen Prophy1axe affektiver Psychosen. Stuttgart: Georg Thieme Verlag, 1994: 61–4
Wehr TA, Goodwin FK. Rapid cycling in manic-depressives induced by tricyclic antidepressants. Arch Gen Psychiatry 1979; 36: 555–9
Post RM, Ketter TA, Pazzaglia PJ, et al. New developments in the use of anticonvulsants as mood stabilizers. Neuropsychobiology 1993; 27: 132–7
Henry JA. A fatal toxicity index for antidepressant poisoning. Acta Psychiatr Scand 1989; 80: 37–45
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Kasper, S., Stamenkovic, M. & Fischer, G. Recurrent Brief Depression. CNS Drugs 4, 222–229 (1995). https://doi.org/10.2165/00023210-199504030-00006
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DOI: https://doi.org/10.2165/00023210-199504030-00006