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Necrotizing Enterocolitis in Acute Lymphoblastic Leukemia Patients: Department Experience

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Abstract

Necrotizing enterocolitis is a severe complication of high-dose chemotherapy in patients with hematopoietic malignancies. Some patients with severe mucositis may develop necrosis of the intestine, leading to typhlitis and perforation of the intestinal tract. The patients have few obvious symptoms; thus, early diagnosis and prompt treatment of intestinal necrosis or bowel perforation seem critical for a good overall treatment outcome. We present 5 cases of intraabdominal complications in patients with acute lymphoblastic leukemia. All patients who underwent surgery survived the postoperative period. We also present a suggested algorithm for treatment of acute abdomen complications in leukemic patients.

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References

  1. Buyukasik Y, Ozcebe OI, Haznedaroglu IC, et al. Neutropenic enterocolitis in adult leukemias.Int J Hematol. 1997;66:47–55.

    Article  CAS  Google Scholar 

  2. Camera A, Andretta C, Villa RM, et al. Intestinal toxicity during induction chemotherapy with cytarabine-based regiments in adult acute myeloid leukemia.Hematol J. 2003;4:346–350.

    Article  CAS  Google Scholar 

  3. Steinberg D, Gold X, Brodin A. Necrotizing enterocolitis in leukemia.Arch Intern Med. 1973;131:538–544.

    Article  CAS  Google Scholar 

  4. Koseoglu K, Dayanir Y, Taskin F, Demirkiran A. Mechanical small bowel obstruction due to intraluminal thrombus in a patient with acute leukaemia: ultrasonic findings.Clin Radiol. 2003;58:406–408.

    Article  CAS  Google Scholar 

  5. Parker LA, Moniaci VK, Fike DL. Surgical intervention for the treatment of necrotizing enterocolitis.Newborn Infant Nurs Rev. 2003;3:64–70.

    Article  Google Scholar 

  6. Schlatter M, Snyder K, Freyer D. Successful nonoperative management of typhlitis in pediatric oncology patients.J Pediatr Surg. 2002;37:1151–1155.

    Article  Google Scholar 

  7. Van de Wetering MD, Caron HN, Bizeveld M, et al. Severity of enterocolitis is predicted by IL-8 in paediatric oncology patients.Eur J Cancer. 2004;40:571–578.

    Article  CAS  Google Scholar 

  8. Lee JS, Polin RA. Treatment and prevention of necrotizing enterocolitis.Semin Neonatol. 2003;8:449–459.

    Article  Google Scholar 

  9. Bodey GP. Unusual presentations of infection in neutropenic patients.Int J Antimicrob Agents. 200;16:93–95.

    Article  CAS  Google Scholar 

  10. Williams EV, Drew PJ, Gaffney C, Shrestha BM, Mansel RE. Pancolitis associated with docetaxel: a rare cause of megacolon.Breast. 2001;10:346–347.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Departments of General Endocrine and Transplant Surgery, Medical University of Gdańsk, 7 Dębinki St, 80-952, Gdańsk, Poland

    Stanislaw Hac & Zbigniew Śledziński

  2. Departments of Hematology, Medical University of Gdansk, Gdansk, Poland

    Malgorzata Stachera-Grzenkowicz & Andrzej Mital

Authors
  1. Stanislaw Hac
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  2. Malgorzata Stachera-Grzenkowicz
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  3. Andrzej Mital
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  4. Zbigniew Śledziński
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Correspondence to Stanislaw Hac.

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Hac, S., Stachera-Grzenkowicz, M., Mital, A. et al. Necrotizing Enterocolitis in Acute Lymphoblastic Leukemia Patients: Department Experience. Int J Hematol 82, 319–323 (2005). https://doi.org/10.1532/IJH97.E0426

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  • DOI: https://doi.org/10.1532/IJH97.E0426

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