Abstract
Although recurring nephrolithiasis may not be as common as single-episode disease, it poses greater problems to the patient's daily lifestyle and general future health status. The general need for an adequate history, examination, and radiological assessment is acknowledged, but a more intensive investigative and management approach is required. Investigations for secondary causes are paramount and may lead to identification of unusual metabolic abnormalities and specific therapies. Such medical approaches entail consideration of dietary adjustments to lower the urinary excretion of components of the renal stones, pharmacological therapies to modulate urinary constituents and limit renal stone risk, and monitoring efficacy of the therapy over time. This approach will prevent significant deterioration of renal function and other serious metabolic consequences.
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Bihl G, Meyers A. 2001 Recurrent renal stone disease-advances in patho genesis and clinical management. Lancet 358:651–656.
Gambaro G, Favaro S, D'Angelo A. 2001 Risk for renal failure in nephrolithiasis. Am J Kidney Dis 37:233–243.
Parks JH, Coe FL. 1996 The financial effects of kidney stone prevention. Kidney Int 50:1706–1712.
Pak CYC, Resnick MI. 2000 Medical therapy and new approaches to management of urolithiasis. Urol Clin North Am 27:243–253.
Levy FL, Adams-Huet B, Pak CYC. 1995 Ambulatory evaluation of nephrolithiasis: an update of a 1980 protocol. Am J Med 98:50–59.
Trinchieri A, Ostini F, Nespoli R, Rovera F, Montanari E, Zametti G. 1999 A prospective study of recurrence rate and risk factors for recurrence after a first renal stone. J Urol 162:27–30.
Ettinger B. 1979 Recurrence of nephrolithiasis. Am J Med 67:245–248.
Ljunghall S, Lithell H, Skarfors E. 1987 Prevalence of renal stones in 60-year-old men. Br J Urol 60:10–13.
Curhan GC, Willett WC, Rimm EB, Stampfer MJ. 1997 Family history and risk of kidney stones. J Am Soc Nephrol 8:1568–1573.
Parks JH, Coe FL. 1994 An increasing number of calcium oxalate stone events worsens treatment outcome. Kidney Int 45:1722–1730.
Matlaga BR, Assimos DG. 2003 Urologic manifestations of nonurologic disease: Urolithiasis. Urol Clin North Am 30:91–99.
Maalouf N, Pak CYC: Nephrolithiasis, in Clinical Nephrology, Dialysis, and Transplantation, Malluche HH, Sawaya BP, Hakim RM, Sayegh MH, eds, Dustri-Verlag, Rockledge, FL.
Moe OW, Abate N, Sakhaee K. 2002 Pathophysiology of uric acid nephrolithiasis. Endocrinol Metab Clin N Am 31:895–914.
Abate N, Chandalia M, Cabo-Chan AV, Moe OW, Sakhaee K. 2004 The metabolic syndrome and uric acid nephrolithiasis: novel features of renal manifestation of insulin resistance. Kidney Int 65:386–392.
Leusmann DB, Niggemann H, Roth S, von Ahlen H. 1995 Recurrence rates and severity of urinary calculi. Scand J Urol Nephrol 29:279–283.
Pak CYC, Skurla C, Harvey J. 1985 Graphic display of urinary risk factors for renal stone formation. J Urol 134:867–870.
Pak CY. 1982 Should patients with single renal stone occurrence undergo diagnostic evaluation. J Urol 127:855–858.
Yagisawa T, Chandhoke PS, Fan J. 1998 Metabolic risk factors in patients with first-time and recurrent stone formations as determined by comprehensive metabolic evaluation. Urology 52:750–755.
Strauss AL, Coe FL, Deutsch L, Parks JH. 1982 Factors that predict relapse of calcium nephrolithiasis during treatment. Am J Med 72:17–24.
Coe FL, Keck J, Norton ER. 1977 The natural history of calcium urolithiasis. JAMA 238:1519–1523.
Pak CYC. 1997 Medical management of nephrolithiasis—A new simplified approach for general practice. Am J Med Sci 313:215–219.
Pak CYC, Asplin JR, Ogawa Y, Resnick MI, Rodgers AL, Traxer O. 2001 Evaluation of stone-forming patients. Paris Consultation on Stone Disease. Paris, France
Pak CY, Kaplan R, Bone H, Townsend J, Waters O. 1975 A simple test for the diagnosis of absorptive, resorptive and renal hypercalciurias. New Engl J Med 292:497–500.
Pak CYC, Ohata M, Lawrence EC, Snyder W. 1974 The hypercalciurias: causes, parathyroid functions, and diagnostic criteria. J Clin Invest 54:387–400.
Lawoyin S, Sismilich S, Browne R, Pak CY. 1979 Bone mineral content in patients with calcium urolithiasis. Metabolism 28:1250–1254.
Pietschmann F, Breslau NA, Pak CYC. 1992 Reduced vertebral bone density in hypercalciuric nephrolithiasis. J Bone Miner Res 7:1383–1388.
Reed BY, Gitomer WL, Heller HJ, et al. 2002 Identification and characterization of a gene with base substitutions associated with the absorptive hypercalciuria phenotype and low spinal bone density. J Clin Endocrinol Metab 87:1476–1485.
Borghi L, Meschi T, Amato F, Briganti A, Novarini A, Giannini A. 1996 Urinary volume, water and recurrences in idiopathic calcium nephrolithiasis: a 5-year randomized prospective study. J Urol 155:839–843.
Borghi L, Schianchi T, Meschi T, et al. 2002 Comparison of two diets for the prevention of recurrent stones in idiopathic hypercalciuria. New Engl J Med 346:77–84.
Wabner CL, Pak CYC. 1993 Effect of orange juice consumption on urinary stone risk factors. J Urol 149:1405–1408.
Insogna KL, Ellison AS, Burtis WJ, Sartori L, Lang RL, Broadus AE. 1989 Trichlormethizide and oral phosphate therapy in patients with absorptive hypercalciuria. J Urol 141:269–274.
Ettinger B, Citron JT, Livermore B, Dolman LI. 1988 Chlorthalidone reduces calcium oxalate calculous recurrence but magnesium hydroxide does not. J Urol 139:679–684.
Pearle MS, Roehrborn CG, Pak CYC. 1999 Meta-analysis of randomized trials for medical prevention of calcium oxalate nephrolithiasis. J Endourol 13:679–685.
Pak CYC, Peters P, Hurt G, et al. 1981 Is selective therapy of recurrent nephrolithiasis possible? Am J Med 71:615–622.
Nicar M, Peterson R, Pak CYC. 1984 Use of potassium citrate as potassium supplement during thiazide therapy of calcium nephrolithiasis. J Urol 131:430–433.
Odvina CV, Preminger GM, Lindberg JS, Moe OW, Pak CYC. 2003 Long-term combined treatment with thiazide and potassium citrate in nephrolithiasis does not lead to hypokalemia or hypochloremic metabolic alkalosis. Kidney Int 63:240–247.
Pak CYC, Heller HJ, Pearle MS, Odvina CV, Poindexter JR, Peterson RD. 2003 Prevention of stone formation and bone loss in absorptive hypercalciuria by combined dietary and pharmacological interventions. J Urol 169:465–469.
Borghi L, Meschi T, Guerra A, Novarini A. 1993 Randomized, prospective study of a nonthiazide diuretic, indapamide, in preventing calcium stone recurrences. J Cardiovasc Pharmacol 22:S78-S86.
Ruml LA, Pearle MS, Pak CYC. 1997 Urolithiasis. Urol Clin North Am 24:117–133.
Barcelo P, Wuhl O, Servitge E, Rousaud A, Pak CYC. 1993 Randomized double blind study of potassium citrate in idiopathic hypocitraturic calcium nephrolithiasis. J Urol 150:1761–1764.
Ettinger B, Pak CYC, Citron JT, Thomas C, Adams-Huet B, Vangessel A. 1997 Potassium-Magnesium citrate is an effective prophylaxis against recurrent calcium oxalate nephrolithiasis. J Urol 153:2069–2073.
Yendt ER, Cohanim M. 1985 Response to a physiologic dose of pyridoxine in type I primary hyperoxaluria. New Engl J Med 312:953–957.
Sutton RA, Walker VR. 1994 Enteric and mild hyperoxaluria. Mineral Electrolyte Metab 20:352–360.
Sidhu H, Schmidt ME, Cornelius JG, et al. 1999 Direct correlation between hyperoxaluria/oxalate stone disease and the absence of the gastrointestinal tract-dwelling bacterium Oxalo bacter formigenes: possible prevention by gut recolonization or enzyme replacement therapy. J Am Soc Nephrol 10:S334-S340.
Ettinger B, Tang A, Citron JT, Livermore B, Williams T. 1986 Randomized trial of allopurino in the prevention of calcium oxalate calculi. New Engl J Med 315:1386–1389.
Pak CY, Peterson R. 1986 Successful treatment of hyperuricosuric calcium oxalate nephrolithiasis with potassium citrate. Arch Intern Med 146:863–867.
Khatchadourian J, Preminger GM, Whitson PA, Adams-Huet B, Pak CYC. 1995 Clinical and biochemical presentation of gouty diathesis: comparison of uric acid versus pure calcium stone formation. J Urol 154:1665–1669.
Pak CYC, Sakhaee K, Fuller C. 1986 Successful management of uric acid nephrolithiasis with potassium citrate. Kidney Int 30:422–428.
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Cameron, M.A., Pak, C.Y.C. Approach to the patient with recurrent neprolithiasis. Clinic Rev Bone Miner Metab 2, 279–289 (2004). https://doi.org/10.1385/BMM:2:3:279
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DOI: https://doi.org/10.1385/BMM:2:3:279