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Histone Deacetylase 1

  • Chapter
Histone Deacetylases

Part of the book series: Cancer Drug Discovery and Development ((CDD&D))

Abstract

HDAC1 was the first histone deacetylase identified in mammals and is considered the prototype of this large family of enzymes. Transcriptional repression mediated by HDAC1 plays a crucial role in the regulation of a variety of biological processes, including cell cycle progression, proliferation, and differentiation. Interestingly, HDAC1 can also influence other cellular activities, such as DNA replication and chromosome segregation, via mechanisms that do not involve transcriptional repression. In addition, HDAC1 is essential for embryonic development and appears to play a critical role in cellular defense against viral infection. Finally, increasing evidence points toward the importance of HDAC1 in tumor formation and/or progression, and cumulative observations indicate that the enzyme is a crucial target for HDAC inhibitors in cancer therapy.

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Abbreviations

BRCA1:

Breast cancer 1 gene

CoREST:

Corepressor of RE1 silencing transcription factor

EED:

Embryonic ectoderm development protein

EZH2:

Enhancer of zeste homo log 2 (Drosophila)

HAT:

Histone acetyltransferase

HDA-1:

Histone deacetylase 1 (Yeast)

MAD:

MAX dimerization protein

MAX:

MYC-associated factor X

MBD3:

Methyl-CpG-binding domain protein 3

MDM2:

Mouse double minute 2

Mi-2-alpha:

Dermatomyositis-specific autoantigen 2 alpha, also called

(CHD3):

chromodomain helicase DNA-binding protein 3

Mi-2-beta:

Dermatomyositis-specific autoantigen 2 beta, also called

(CHD4):

chromodomain helicase DNA-binding protein 4

MTA1, MTA2:

Metastasis-associated gene 1, metastasis-associated gene 2

MYC:

Myelocytomatosis oncogene

NF-Y:

Nuclear transcription factor Y

P/CAF:

p300/CBP-associated factor

RPD3:

Reduced potassium dependency 3

SAP18:

SIN3-associated polypeptide, 18 KDa

SAP30:

SIN3-associated polypeptide, 30 KDa

SIN3:

SWI-independent 3

SP1:

SP3 Specific protein 1, specific protein 3

YY1:

Ying yang 1

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  1. Gladstone Institute of Virology and Immunology, University of California, San Francisco, CA

    Eric Verdin MD

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© 2006 Humana Press Inc., Totowa, NJ

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Meunier, D., Seiser, C. (2006). Histone Deacetylase 1. In: Verdin, E. (eds) Histone Deacetylases. Cancer Drug Discovery and Development. Humana Press. https://doi.org/10.1385/1-59745-024-3:3

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