Abstract
Thrombolysis is the first scientifically established treatment for acute ischemic stroke, but we now need to build on that success. One possible way this might be accomplished is by combining thrombolysis with neuroprotection (see Chapter 3). Such combination therapy might reduce complications of thrombolysis, especially hemorrhage, by protecting damaged endothelium or reducing the volume of tissue necrosis. It might also prevent secondary injury associated with reperfusion. Finally, it might augment the benefit of thrombolysis by extending the time window before irreversible damage occurs. This chapter explores the rationale behind combination therapy and describe laboratory and clinical results to date.
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© 2005 Humana Press Inc., Totowa, NJ
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Grotta, J.C., Labiche, L.A. (2005). Combination of Thrombolytic Therapy With Neuroprotectants. In: Lyden, P.D. (eds) Thrombolytic Therapy for Acute Stroke. Current Clinical Neurology. Humana Press. https://doi.org/10.1385/1-59259-933-8:77
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DOI: https://doi.org/10.1385/1-59259-933-8:77
Publisher Name: Humana Press
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