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Clinicopathological Features and Outcome of Lung Cancer Patients with Hematological Malignancy

  • Thoracic Oncology
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Purpose

The aim of this study was to report the incidence of lung cancer in patients with hematological malignancy (HM), as well as patient characteristics and outcome.

Methods

We investigated 1503 consecutive patients treated for HM and 1208 patients who underwent surgical resection for lung cancer.

Results

Lung cancer with HM was observed in 12 patients (0.8 % of HM cases and 1.0 % of lung cancer cases), including eight men who were smokers and four women who had never smoked. The average Brinkman index was 1010, which suggested heavy smokers. In synchronous cases, all four patients preceded to HM treatment; however, three patients died from HM. In metachronous cases, during a mean 52.7 months after treatment of lung cancer, three patients had HM. At a mean 41.4 months after HM treatment, five patients had lung cancer and underwent surgery without serious postoperative events.

Conclusions

A second cancer tended to be detected within 5 years after treatment of the first cancer. Men with a history of heavy smoking might be at risk for combined lung cancer and HM. Careful follow-up is recommended within 5 years after treatment of the first cancer. Most lung cancer detected synchronously with HM had poor prognosis. In metachronous cases, surgical resection of lung cancer after treatment of HM was feasible and safe.

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Disclosures

Fumihiro Shoji, Koji Yamazaki, Hidenori Kouso, Ryo Mori, Ken Takase, Seiichi Okamura, and Sadanori Takeo disclose no financial and personal relationships with other people or organizations that could have inappropriately influenced their work.

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Authors and Affiliations

  1. Department of Thoracic Surgery, Clinical Research Institute, National Hospital Organization Kyushu Medical Center, Fukuoka, Japan

    Fumihiro Shoji MD, PhD, Koji Yamazaki MD, PhD, Hidenori Kouso MD, PhD, Ryo Mori MD & Sadanori Takeo MD, PhD

  2. Department of Hematology, Clinical Research Institute, National Hospital Organization Kyushu Medical Center, Fukuoka, Japan

    Ken Takase MD, PhD & Seiichi Okamura MD, PhD

Authors
  1. Fumihiro Shoji MD, PhD
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  2. Koji Yamazaki MD, PhD
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  3. Hidenori Kouso MD, PhD
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  4. Ryo Mori MD
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  5. Ken Takase MD, PhD
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  6. Seiichi Okamura MD, PhD
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  7. Sadanori Takeo MD, PhD
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Corresponding author

Correspondence to Fumihiro Shoji MD, PhD.

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Shoji, F., Yamazaki, K., Kouso, H. et al. Clinicopathological Features and Outcome of Lung Cancer Patients with Hematological Malignancy. Ann Surg Oncol 23, 633–637 (2016). https://doi.org/10.1245/s10434-015-4885-5

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  • DOI: https://doi.org/10.1245/s10434-015-4885-5

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