Abstract.
Topical medicine application has been used to treat a good number of pathological processes. Its efficacy is associated to an efficient penetration of the drug in the internal skin layers, promoting systemic effects and excluding the possibility of drug degradation by the digestive tract and hepatic elimination. This work analyzes the penetration kinetics of two soluble bases employed as vehicles for topic application: superficial gel (Carbopol 940) and transdermic (transdermal) gel. Analysis was performed with the photoacoustic technique, based upon the absorption of modulated light by a sample with subsequent conversion of the absorbed energy in heat, generating acoustic waves in the air layer adjacent to the sample. Each of the two vehicles was evaluated through in vivo (human skin) and in vitro application. Measurements in vitro employed samples of VitroSkin (synthetic material with properties similar to those of real skin, employed in the pharmaceutical industry research). Results show that the permeation was faster for the transdermal gel, both for in vivo and in vitro measurements, indicating that in vitro measurements may be utilized in qualitative, comparative permeation studies.
Similar content being viewed by others
References
S. Mitagotri, J. Contr. Release 71, 23 (2001)
L. Machet, A. Boucaud, Int. J. Pharm. 243, 1 (2002)
A. Ferreira, Guia prático da Farmácia Magistral (Ortofarma, Juiz de Fora, 2000)
K. Kolmel et al., J. Soc. Cosmet. 37, 375 (1986)
B. Sennhenn et al., Skin Pharm. 6, 152 (1993)
B.D. Hanh et al., J. Contr. Release 70, 393 (2001)
E.V. Savateeva, A.A. Karabutov, A.A. Oraevsky, in Proc. SPIE 4256, 61 (2001)
F.H. Anjos et al., J. Phys. IV (France) 125, 797 (2005)
J.C.B. Rocha et al., Analytica Chimica Acta 587, 132 (2007)
M. Kreilgaard, Pharm. Res. 18, 367 (2001)
J.C. Bernengo et al., High Temp.-High Press. 30, 619 (1998)
P.R. Barja et al., J. Phys. IV (France) 125, 789 (2005)
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Rossi, R., de Paiva, R., da Silva, M. et al. Photoacoustic study of percutaneous absorption of Carbopol and transdermic gels for topic use in skin. Eur. Phys. J. Spec. Top. 153, 479–482 (2008). https://doi.org/10.1140/epjst/e2008-00489-1
Issue Date:
DOI: https://doi.org/10.1140/epjst/e2008-00489-1