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Non-extensive trends in the size distribution of coding and non-coding DNA sequences in the human genome

  • Biophysics
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Abstract.

We study the primary DNA structure of four of the most completely sequenced human chromosomes (including chromosome 19 which is the most dense in coding), using non-extensive statistics. We show that the exponents governing the spatial decay of the coding size distributions vary between 5.2 ≤r ≤5.7 for the short scales and 1.45 ≤q ≤1.50 for the large scales. On the contrary, the exponents governing the spatial decay of the non-coding size distributions in these four chromosomes, take the values 2.4 ≤r ≤3.2 for the short scales and 1.50 ≤q ≤1.72 for the large scales. These results, in particular the values of the tail exponent q, indicate the existence of correlations in the coding and non-coding size distributions with tendency for higher correlations in the non-coding DNA.

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Authors and Affiliations

  1. Institute of Physical Chemistry, National Center for Scientific Research “Demokritos”, 15310, Athens, Greece

    Th. Oikonomou & A. Provata

  2. Department of Biological Chemistry, University of Athens, School of Medicine, Goudi, 11527, Athens, Greece

    Th. Oikonomou

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  1. Th. Oikonomou
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  2. A. Provata
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Correspondence to Th. Oikonomou.

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Oikonomou, T., Provata, A. Non-extensive trends in the size distribution of coding and non-coding DNA sequences in the human genome. Eur. Phys. J. B 50, 259–264 (2006). https://doi.org/10.1140/epjb/e2006-00121-2

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