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Synthesis, Characterization, and Anti-Diabetic Therapeutic Activity of New Vanadyl(II) Complexes with Orotic Acid and Different Amino Acids Mixed Ligands

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Abstract

Mixed ligand vanadyl(II) complexes of orotic acid and six different amino acids (isoleucine, threonine, proline, phenylalanine, lysine, and glutamine) have been synthesized. Vanadyl(II) orotate mixed ligand complexes are studied on the basis of conductivity, FTIR, UV-Vis, TG-DTG-DTA, magnetic moments, solid powder XRD, SEM, and TEM measurements. These non-electrolyte complexes are of 1 : 1 : 1 stochiometry. The major goal of this article is design and synthesis of new insulin alternative anti-diabetic drug. The insulin hormone and blood glucose level, lipid profile, liver and kidney functions, and superoxide dismutase antioxidant (SOD) are the factors to identify efficiency of the new synthesized compounds as antidiabetic drug agents.

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Funding

This work was funded by the Deanship of Scientific Research at Princess Nourah bint Abdulrahman University, through the Research Groups Program (grant no. RGP-1440-0003).

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Authors and Affiliations

  1. Department of Chemistry, College of Science, Princess Nourah Bint Abdulrahman University, Riyadh, 11671, Saudi Arabia

    A. S. Al-Wasidi, N. M. Al-Jafshar & A. M. Al-Anazi

  2. Chemistry Department, Faculty of Science, Taif University, P.O. Box 888, Al-Hawiah, Taif, 21974, Saudi Arabia

    M. S. Refat

  3. Department of Chemistry, Faculty of Science, Port Said University, Port Said, Egypt

    M. S. Refat & L. A. Ismail

  4. Department of Pharmaceutical Chemistry, Drug Exploration and Development Chair (DEDC), College of Pharmacy, King Saud University, Riyadh, 11451, Saudi Arabia

    M. A. Al-Omar & A. M. Naglah

  5. Peptide Chemistry Department, Chemical Industries Research Division, National Research Centre, Dokki, Cairo, 12622, Egypt

    A. M. Naglah & Atef Kalmouch

Authors
  1. A. S. Al-Wasidi
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  2. N. M. Al-Jafshar
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  3. A. M. Al-Anazi
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  4. M. S. Refat
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  5. L. A. Ismail
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  6. M. A. Al-Omar
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  7. A. M. Naglah
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  8. Atef Kalmouch
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Correspondence to M. S. Refat.

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Al-Wasidi, A.S., Al-Jafshar, N.M., Al-Anazi, A.M. et al. Synthesis, Characterization, and Anti-Diabetic Therapeutic Activity of New Vanadyl(II) Complexes with Orotic Acid and Different Amino Acids Mixed Ligands. Russ J Gen Chem 89, 2121–2128 (2019). https://doi.org/10.1134/S1070363219100219

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  • DOI: https://doi.org/10.1134/S1070363219100219

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