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Design and synthesis of novel fused heterocycles using 4-chromanone as synthon

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Abstract

A new series of heterocyclic systems, including azole, azolopyrimidine, and pyridopyrimidine derivatives, attached to 2H-chromene scaffold, was prepared by a convenient procedure through the reactions of (E)-2-dimethylamino-methylene chromanone with different nitrogen binucleophiles. Various substituted chromeno[4,3-b]pyridine derivatives were also prepared through the reactions of (E)-2-dimethylaminomethylene chromanone with a series of active methylene compounds.

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Authors and Affiliations

  1. Applied Organic Chemistry Department, National Research Centre, Dokki, Giza, 12622, Egypt

    K. A. Ali, N. A. A. Abdelhafez, A. A. Ibrahim & A. E. Amr

  2. Chemistry Department, Faculty of Science, Cairo University, Giza, Egypt

    E. A. Ragab

  3. Pharmaceutical Chemistry Department, College of Pharmacy, Drug Exploration & Development Chair (DEDC), King Saud University, Riyadh, 11451, Saudi Arabia

    A. E. Amr

Authors
  1. K. A. Ali
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  2. N. A. A. Abdelhafez
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  3. E. A. Ragab
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  4. A. A. Ibrahim
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  5. A. E. Amr
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Corresponding author

Correspondence to A. E. Amr.

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The text was submitted by the authors in English.

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Ali, K.A., Abdelhafez, N.A.A., Ragab, E.A. et al. Design and synthesis of novel fused heterocycles using 4-chromanone as synthon. Russ J Gen Chem 85, 2853–2860 (2015). https://doi.org/10.1134/S107036321512035X

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  • DOI: https://doi.org/10.1134/S107036321512035X

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