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An Eco-Friendly Synthesis of Some Novel Chromene-Based Heterocyclic Compounds of Biological Interest

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Abstract

The target chromonylchalcone 3-(3-(4-oxo-4H-chromen-3-yl)-acryloyl)-2H-chromen-2-one was synthesized by reacting 3-acetylcoumarin with 3-formylchromone. The chromonylchalcone was reacted with active methylene reagents, thiourea, hydrazines, aromatic amines, and sodium azide to afford new heterocyclic compounds. The newly prepared compounds were screened for their anti-microbial and anti-inflammatory activities.

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ACKNOWLEDGMENTS

Thanks are also due to Professor Peter Metz, Institute für Organische Chemie, TU Dresden, for his repeated invitations and generous hospitalities. A.F. El Farargy thanks Professor Norbert Krause, Lehrstuhl für Organische Chemie, TU Dortmund, for his repeated invitations, kind hospitalities, and the offered facilities.

Funding

F.M. Abdelrazek thanks Alexander von Humboldt Foundation (Germany) for the continuous help and support through granting short research fellowships.

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Authors and Affiliations

  1. Chemistry Department, Faculty of Women for Arts, Science and Education, Ain Shams University, 11767, Cairo, Egypt

    E. Mansour & E. M. Nassar

  2. Chemistry Department, Faculty of Science, Zagazig University, 44519, Zagazig, Egypt

    A. F. El-Farargy

  3. Chemistry Department, Faculty of Science, Cairo University, 12613, Giza, Egypt

    F. M. Abdelrazek

Authors
  1. E. Mansour
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  2. E. M. Nassar
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  3. A. F. El-Farargy
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  4. F. M. Abdelrazek
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Corresponding author

Correspondence to E. Mansour.

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This article does not contain any studies involving animals or human participants performed by any of the authors.

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The authors declare that they have no conflict of interests.

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Corresponding author: phone: 00201115728866; e-mail: emanmansour211@yahoo.com.

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Mansour, E., Nassar, E.M., El-Farargy, A.F. et al. An Eco-Friendly Synthesis of Some Novel Chromene-Based Heterocyclic Compounds of Biological Interest. Russ J Bioorg Chem 46, 582–589 (2020). https://doi.org/10.1134/S1068162020040135

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  • DOI: https://doi.org/10.1134/S1068162020040135

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