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Bacterial Biofilm Inhibition, Hemolytic Activity, and Structure–Activity Relationship of N-(2,3-Dihydro-1,4-Benzodioxin-6-yl)-4-Nitro-N-(Substituted-Benzyl)benzenesulfonamides

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Abstract

In the work, new antibacterial compounds that combine sulfonamide and benzodioxane fragments in their framework were fabricated. Structures of the sulfonamide derivatives were determined by the IR, 1H NMR, 13C NMR, and EI-MS spectroscopy techniques. Antibacterial potential of these molecules was ascertained by biofilm inhibition study against Escherichia coli and Bacillus subtilis. The results revealed that two of the compounds were rather active inhibitors of these two pathogenic bacterial strains. According to the hemolytic study, most of the new molecules are mildly cytotoxic and hence might be used as safe antibacterial agents.

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ACKNOWLEDGMENTS

The authors are thankful to Higher Education Commission of Pakistan for the financial support for this study.

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Authors and Affiliations

  1. Department of Chemistry, Government College University, 54000, Lahore, Pakistan

    Muhammad A. Abbasi,  Aziz-ur-Rehman & Sabahat Z. Siddiqui

  2. Division of Science and Technology, University of Education, Township Campus, 54770, Lahore, Pakistan

    M. Irshad

  3. Faculty of Pharmacy and Atta-ur-Rahman Institute for Natural Products Discovery (AuRIns), Universiti Teknologi MARA, Puncak Alam Campus, 42300, Selangor Darul Ehsan, Bandar Puncak Alam, Malaysia

    Syed A. Ali Shah

  4. Department of Biochemistry, University of Agriculture, 38040, Faisalabad, Pakistan

    M. Shahid

Authors
  1. Muhammad A. Abbasi
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  2. M. Irshad
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  3. Aziz-ur-Rehman
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  4. Sabahat Z. Siddiqui
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Correspondence to Muhammad A. Abbasi.

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This article does not contain any studies involving human participants performed by any of the authors and does not contain any studies involving animals performed by any of the authors.

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The authors declare that they have no conflicts of interest.

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Corresponding author: e-mail: abbasi@gcu.edu.pk.

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Muhammad A. Abbasi, Irshad, M., Aziz-ur-Rehman et al. Bacterial Biofilm Inhibition, Hemolytic Activity, and Structure–Activity Relationship of N-(2,3-Dihydro-1,4-Benzodioxin-6-yl)-4-Nitro-N-(Substituted-Benzyl)benzenesulfonamides. Russ J Bioorg Chem 46, 223–234 (2020). https://doi.org/10.1134/S1068162020020028

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