Abstract
In this paper, partly esterified β-cyclodextrin derivative had been synthesized by esterification of β-cyclodextrin and maleic anhydride. Then, it is amidated by diethanolamine. β-Cyclodextrin copolymer had been prepared from amidated β-cyclodextrin derivative, cholic acid and epichlorohydrin in sodium hydroxide aqueous solution. β-Cyclodextrin hydrogel had been prepared through radical polymerization of β-cyclodextrin copolymer, N-isopropylacrylamide and acrylic acid. The structures, compositions and morphology of the hydrogel were characterized by infrared spectroscopy, nuclear magnetic resonance, differential scanning calorimetry and field-emission scanning electron microscope. Its properties were tested and analyzed by ultraviolet spectroscopy, thermogravimetric analysis and swelling experiments. The results show that the β-cyclodextrin hydrogel owns sustained release performance, temperature and pH sensitivities.
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Funding
The research is especially grateful for the sponsored by Jiangsu Province Graduate Cultivation Innovative Project (KYCX202511), Support Program (Industrial) of Changzhou Science and Technology (CE20200014), Double “Ten Hundred and Thousand” Project of Wujin District Science and Technology Bureau, the Top-notch Academic Programs Project of Jiangsu Higher Education Institutions (TAPP), the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD), Jiangsu Chenguang Paint Co., Ltd., Changzhou, Jiangsu and Shenzhen Basic Research Project (JCYJ20170818114324998).
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Qiuyue Guo, Chen, Y., Li, X. et al. Preparation and Properties of Double Sensitive β-Cyclodextrin Hydrogel. Polym. Sci. Ser. A 63, 143–153 (2021). https://doi.org/10.1134/S0965545X21020036
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DOI: https://doi.org/10.1134/S0965545X21020036