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Proteolytic signaling mechanisms in skeletal muscles in patients with alcohol-induced muscle disease

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Abstract

Chronic alcoholic myopathy is one of the most numerous and profound manifestations of chronic alcohol intoxication. This disease is characterized by the pronounced atrophy of the locomotor muscles, which involves fibers expressing predominantly type II (fast) myosin isoforms. In early experiments with rats receiving alcohol and studies of patients, the impairment of the anabolic intracellular signaling pathways and decrease in protein synthesis rate were shown. We were the first to analyze the signaling pathways involved in the pathogenesis of alcoholic myopathy with different fiber atrophy levels. At the early stages of pathogenesis, we observed also a sufficient increase in mRNA of E3 ubiquitin ligases. However, the ubiquitinylation level was not altered in patients as compared to the control subjects. This phenomenon could be related to an increased expression of heat shock proteins known for their protective action.

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Authors and Affiliations

  1. Institute of Biomedical Problems, Russian Academy of Sciences, Moscow, 123007, Russia

    B. S. Shenkman, Y. N. Lomonosova & E. A. Lysenko

  2. Sechenov First Moscow State Medical University, Moscow, 119991, Russia

    Y. V. Kazantseva, O. E. Zinovyeva & N. N. Yakhno

Authors
  1. B. S. Shenkman
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  2. Y. N. Lomonosova
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  3. E. A. Lysenko
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  4. Y. V. Kazantseva
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  5. O. E. Zinovyeva
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  6. N. N. Yakhno
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Additional information

Original Russian Text © B.S. Shenkman, Y.N. Lomonosova, E.A. Lysenko, Y.V. Kazantseva, O.E. Zinovyeva, N.N. Yakhno, 2013, published in Fiziologiya Cheloveka, 2013, Vol. 39, No. 5, pp. 112–118.

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Shenkman, B.S., Lomonosova, Y.N., Lysenko, E.A. et al. Proteolytic signaling mechanisms in skeletal muscles in patients with alcohol-induced muscle disease. Hum Physiol 39, 545–550 (2013). https://doi.org/10.1134/S0362119713050149

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  • DOI: https://doi.org/10.1134/S0362119713050149

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