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Synthesis of Substituted Derivatives of closo-Decaborate Anion with a Peptide Bond: The Way towards Designing Biologically Active Boron-Containing Compounds

  • SYNTHESIS AND PROPERTIES OF INORGANIC COMPOUNDS
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Abstract

A novel scheme of multi-step synthesis for N-borylated dipeptide R-GlyPheOEt is proposed, which is based on the nucleophilic addition of amino acid derivatives to the [2-B10H9NCCH3]– anion. The products obtained at each step were studied by NMR, IR spectroscopy, and ESI mass spectrometry. The single-crystal structure of (NBu4)[2-B10H9NH=C(NH2CH2COOtC4H9)CH3] was identified by XRD.

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ACKNOWLEDGMENTS

The studies were conducted using the facilities of the Shared Physical Analysis Facilities Center of the Kurnakov Institute of General and Inorganic Chemistry, which functions under the State Assignment to the Kurnakov Institute in the field of basic research.

Funding

This work was supported by the Russian Foundation for Basic Research (project no. 19-03-00218_a) and the Council of Russian Federation Presidential Grants (project nos. MK-2403.2019.3 and NSh-2845.2018.3).

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Authors and Affiliations

  1. Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, 119991, Moscow, Russia

    A. V. Nelyubin, I. N. Klyukin, A. P. Zhdanov, K. Yu. Zhizhin & N. T. Kuznetsov

  2. Frumkin Institute of Physical Chemistry and Electrochemistry, Russian Academy of Sciences, 119991, Moscow, Russia

    M. S. Grigor’ev

Authors
  1. A. V. Nelyubin
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  2. I. N. Klyukin
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  3. A. P. Zhdanov
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Corresponding author

Correspondence to A. P. Zhdanov.

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This article summarizes the results of the research paper competition held under the IX Conference of Young Scientists on General and Inorganic Chemistry (Kurnakov Institute of General and Inorganic Chemistry, Moscow, Russia, 2019).

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Translated by D. Terpilovskaya

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Nelyubin, A.V., Klyukin, I.N., Zhdanov, A.P. et al. Synthesis of Substituted Derivatives of closo-Decaborate Anion with a Peptide Bond: The Way towards Designing Biologically Active Boron-Containing Compounds. Russ. J. Inorg. Chem. 64, 1499–1506 (2019). https://doi.org/10.1134/S003602361912012X

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